三维适形调强放疗联合替吉奥治疗老年食管癌的效果观察  

Study the efficacy effect of using S-1 combined with intensity-modulated radiotherapy in treatment of the elder patients with esophageal cancer

作　　者：丁华[1] DING Hua(Nantong tumor hospital, Jiangsu 226361 ,China)

机构地区：[1]江苏省南通市肿瘤医院放疗科,226361

出　　处：《临床合理用药杂志》2017年第29期9-10,15,共3页Chinese Journal of Clinical Rational Drug Use

摘　　要：目的观察三维适形调强放疗联合替吉奥同步化疗治疗老年食管癌的临床效果。方法选取医院收治的老年食管癌患者89例为研究对象,按治疗方法不同分为单纯放疗组43例和同步放化疗组46例。单纯放疗组接受单一三维适形调强放疗治疗,同步放化疗组接受三维适形调强放疗联合替吉奥同步化疗治疗。观察比较2组患者的近期临床疗效、1年和2年生存率以及不良反应发生情况。结果同步放化疗组部分缓解率、总有效率分别为54.35%、82.61%,均高于单纯放疗组的32.56%、58.14%(P<0.05);同步放化疗组1年生存率和2年生存率分别为82.61%、56.52%,均高于单纯放疗组的53.49%、32.56%(P<0.01或P<0.05);同步放化疗组白细胞下降(Ⅲ~Ⅳ级)发生率、恶心和呕吐(Ⅰ~Ⅱ级)发生率分别为15.22%、47.83%,单纯放疗组的发生率分别为0、4.65%,2组差异有统计学意义(P<0.05)。结论三维适形调强放疗联合吉替奥同步化疗治疗老年食管癌的临床疗效明确可靠,效果较好,不良反应可以耐受,值得临床推广应用。Objective To explore the the efficacy effect of using S-1 combined with intensity-modulated radiotherapy in treatment of the elder patients with esophageal cancer. Methods 89 cases of elder patients with esophageal cancer treated in our hospital were divided into radiotherapy group （43 cases ） and chemoradiotherapy group （46 cases ）. Patients of radio- therapy＂ group were treated with intensity-modulated radiotherapy alone,while patients of chemoradiotherapy group were treated with S-1 combined with intensity-modulated radiotherapy. The short-term effect, 1-year and 2-year survival rate and adverse re- actions in the two groups were observed. Results The partial remission rate,the total effective rate of ehemorediotherapy group were 54.35% and 82.61% ,which were higher than that of radiotherapy group of 32.56% and 58.14% respectively （P 〈 0. 05 ）. The 1-year survival rate and 2-year survival rate were 82.61% and 56.52% in chemorediotherapy group（P 〈0. O1 or P 〈 0. 135 ） ,which were significantly higher than those in the radiotherapy group with 53.49% and 32.56% respectively. Leu- kocyte decrease rate （ II1 - 1V ）, nausea and vomiting rate （ l ~ II ） in chemoradiotherapy group were 15.22% , 47.83% , which were higher than those of 0% and 4.65% in radiotherapy group and the difference was statistically significant （P 〈 0. 05 ）. Conclusion S-1 combined with intensity-modulated radiotherapy has good clinical efficacy in treatment of esophageal cancer in elder patients and adverse reactions can be tolerated, h is worthy of the clinical promotion.

关 键 词：三维适形调强放疗 替吉奥 老年食管癌 

分 类 号：R735.1[医药卫生—肿瘤]