Desmoplakin与FⅧ因子在乳腺癌转移中的作用及两者的相关性  

Role of desmoplakin and FⅧ factor in breast cancer metastasis and their correlation

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作  者:王倩 罗凯 劳淑贞 朴金松 高蔚樱 赵凯 张东辉 谭小军 WANG Qian LUO Kai LAO Shu-zhen PIAO Jin-song GAO Wei-ying ZHAO Kai ZHANG Dong-hui TAN Xiao-jun(Department of Pathology Tumor Research Institute, Cancer Center of Guangzhou Medical University, Guangzhou 510095, China)

机构地区:[1]广州医科大学附属肿瘤医院病理科,广东省广州市510095 [2]广州医科大学附属肿瘤医院肿瘤研究所,广东省广州市510095

出  处:《广西医学》2017年第10期1477-1479,共3页Guangxi Medical Journal

基  金:广州医科大学自然科学青年项目(2015A26)

摘  要:目的探讨桥粒相关转膜糖蛋白(desmoplakin)和血液凝固第Ⅷ因子(FⅧ)在乳腺癌转移中的作用及两者的相关性。方法将100例乳腺癌石蜡标本根据淋巴结转移情况分为转移组与非转移组,每组各50例。比较两组乳腺癌组织中血管与淋巴管生成情况,并探讨两组中desmoplakin和FⅧ因子表达的相关性。结果转移组乳腺癌组织中用desmoplakin和FⅧ标记的淋巴管生成数高于未转移组(P<0.05),但两组血管生成数比较,差异无统计学意义(P>0.05)。Desmoplakin和Ⅷ因子在转移组及未转移组乳腺癌组织中的表达均无相关性(P>0.05)。结论 Desmoplakin有望成为乳腺癌转移的检测指标。Objective To investigate the role of desmoplakin and blood coagulation factor vm (Fvm) in breast cancer metastasis and their correlation. Methods The paraffin specimens from 100 cases of breast cancer were divided into metastasis group and non-metastasis group according to lymph node metastasis status,with 50 cases in each group. The lymphangiogenesis and angiogenesis in breast cancer tissues were compared between the two groups, and the correlation of desmoplakin expression with Fvm expression was discussed in the two groups. Results The number of lymphangiogenesis in the metastasis group was higher than that in the non-metastasis group (P 〈 0.05) ,but there was no significant difference in the number of angiogenesis between the two groups( P 〉 0.05 ). In the two groups, no correlation was observed between desmoplakin expression and FⅧexpression in the breast cancer tissues (P 〉 0.05 ). Conclusion Desmoplakin is expected to serve as an indicator for the detection of breast cancer metastasis.

关 键 词:乳腺癌 转移 桥粒相关转膜糖蛋白 血液凝固第Ⅷ因子 淋巴管 

分 类 号:R737.9[医药卫生—肿瘤]

 

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