卵母细胞代谢及其调节  

Research progress of oocyte metabolism and its regulation

作　　者：徐文丹 崔毓桂[2] 茅彩萍[1] 

机构地区：[1]苏州大学医学院附属第一医院生殖医学中心,苏州215006 [2]南京医科大学第一附属医院生殖医学科,南京210029

出　　处：《生殖医学杂志》2017年第10期1047-1051,共5页Journal of Reproductive Medicine

基　　金：2017江苏省科教强卫工程项目(生殖医学创新平台;医学重点人才项目);江苏省社会发展项目(BE20150642);国家自然基金(81370719;81671535);高校优势学科Ⅱ期建设过程(JX10231802);卫生厅妇幼保健重点专科(FXK201221)

摘　　要：卵母细胞发育与成熟过程依赖大量ATP,因此物质代谢旺盛。卵母细胞以葡萄糖和/或其中间产物丙酮酸为底物,在线粒体内氧化磷酸化,产生大量ATP,是卵母细胞最主要的供能形式。但是,卵母细胞糖代谢模式有种属特异性差异。同时,卵母细胞也存在脂肪酸和氨基酸的代谢。除提供能量外,这些代谢产物在细胞信号传导、渗透压调节等方面也有重要作用。卵母细胞代谢的精确调控受多方面因素的影响如卵母细胞胞内、胞间、胞外的调控等。研究卵母细胞代谢及其机制,对探寻改善卵母细胞质量、提高卵母细胞体外成熟效能具有重要的意义。The development and maturation of oocyte are dependent on ATP which comes from the highly active energy metabolism.It is the main energy procedure that oocytes produce ATP by the mitochondria oxidative phosphorylation with the glucose and/or its intermediate product,acetylformic acid,as substrate.Meanwhile,fatty and amino acids are also metabolic substrates in oocyte.Interestingly,there are species differences in the glycometabolism model.Besides energy,those metabolites and intermediate products play some roles in signal transduction,osmoregulation and so on.The oocyte metabolism is precisely controlled by the intracellular,intercellular and extracellular pathways.It is important to study oocyte metabolism and maturation mechanism in order to improve oocyte quality and efficiency of in vitro maturation(IVM).

关 键 词：卵母细胞 卵丘细胞 线粒体 能量代谢 卵母细胞成熟 

分 类 号：R[医药卫生]