富血小板纤维蛋白在牙周植骨手术中的临床观察  

Clinical observation of platelet rich fibrin in periodontal bone graft surgery

作　　者：雷朝锋 王英博[1] 徐屹[2] 

机构地区：[1]北京大学口腔医院第三门诊部,北京100191 [2]四川大学华西口腔医院牙周科,四川成都610041

出　　处：《牙体牙髓牙周病学杂志》2017年第9期525-528,共4页Chinese Journal of Conservative Dentistry

基　　金：四川省科技支撑项目(2015SZ0137)

摘　　要：目的:观察第二代血小板浓缩物富血小板纤维蛋白(PRF)和植骨材料联合应用在牙周植骨手术中的疗效。方法:纳入20名慢性牙周炎牙槽骨垂直吸收的患者,随机分为试验组和对照组(n=10)。试验组植入PRF碎片和Bio-Oss骨粉混合物,再覆盖PRF膜,对照组仅植入Bio-Oss骨粉。分别于术前和术后6个月进行探诊深度(PD)、附着水平(AL)、Mazza出血指数(BI)检查,并进行骨内袋(IBD)影像学测量。结果:试验组和对照组术后PD、AL、BI、IBD均优于术前(P<0.05)。术后6个月,试验组PD、AL优于对照组(P<0.05),BI、IBD两组间无统计学意义(P>0.05)。结论:治疗慢性牙周炎弧形骨缺损时,PRF配合Bio-Oss骨移植物的使用可以促进软、硬组织的愈合,而对于成骨作用有限。AIM： To observe the effects of second-generation platelet concentrated platelet-rich fibrin（ PRF） on the periodontal tissue healing. METHODS： 20 patients with intra-bony defects of chronic periodontitis were randomly divided into the test and the control groups（ n = 10）. The patients in test group were treated with PRF and Bio-Oss combination,those in the control were treated with Bio-Oss alone. Probing depth（ PD）,attachment level（ AL）,Mazza bleeding index（ BI） and radiographic measurements of intra-bony defect（ IBD） were recorded at pre-surgical baseline and 6 months post-operatively. RESULTS： All the clinical and radiographic parameters of the2 groups were improved after treatment（ P 〈 0. 05）. Mean PD reduction and AL gain in test group were more than in the control group（ P 〈0. 05）. No statistically significant difference was found in BI and IBD between 2 groups. CONCLUSION： PRF combined with Bio-Oss bone graft may accelerate periodontal soft and hard tissue healing.

关 键 词：富血小板纤维蛋白(PRF) 慢性牙周炎 植骨术 

分 类 号：R781.4[医药卫生—口腔医学]