血清尿酸水平与帕金森病不同运动亚型之间的关系  

Association between the serum uric acid level and motor subtype of Parkinson's disease

作　　者：张丽娜[1] 屈洪党[1] 陈育华[1] 殷亮[1] 李倩倩[1] ZHANG Li-na QU Hong-dang CHEN Yu-hua YIN Liang LI Qian-qian(Department of Neurology, The First Affiliated Hospital of Bengbu Medical College, Bengbu Anhui 233004, Chin)

机构地区：[1]蚌埠医学院第一附属医院神经内科,安徽蚌埠233004

出　　处：《蚌埠医学院学报》2017年第7期852-853,857,共3页Journal of Bengbu Medical College

基　　金：国家自然科学基金项目(81641050)

摘　　要：目的:探讨血清尿酸(UA)水平与帕金森病(PD)不同运动亚型及临床分期之间的关系。方法:入选PD病人(PD组)及年龄、性别相匹配的健康对照组(HC组)各50例,PD病人根据运动障碍症状分为震颤为主型(TD组)和姿势异常及步态障碍为主型(PIGD组);病情严重程度采用Hoehn-Yahr(H-Y)分级评定为早期(H-Y<3级)及中晚期(H-Y≥3级)。分别测定各组血清UA水平,同时检测血清肌酐(Cr)水平。结果:PD组血清UA水平低于HC组(P<0.01);PIGD组血清UA水平较TD组明显降低(P<0.05);中晚期PD病人血清UA水平低于早期(P<0.01)。各组血清Cr水平差异无统计学意义(P>0.05)。结论:UA水平的变化可能参与了PD不同运动亚型的发病机制,并可能成为预测PD发病风险、判断病情严重程度及运动分型的生物学标志物。Objective：To investigate the relationships between serum uric acid（ UA） level,and different motor subtypes and clinical stage of Parkinson′s disease（ PD） . Methods：PD patients and age and sex-matched healthy people were divided into the PD group（ n=50）and control group（HC group,n=50）,respectively. The PD group were subdivided into TD group（tremor-dominant） and PIGD group（ postural instability and gait difficulty-dominant） according to the dyskinesia symptom. The disease severity was evaluated by Hoehn-Yahr（H-Y） scale,which could evaluated for early-stage（H-Y〈3） and advanced-stage（H-Y≥3）. The serum levels of UA and creatinine（Cr） in all cases were measured. Results：The serum UA level in PD group was lower than that in HC group（P〈0. 01）. Compared with the TD group,the serum level of UA in PIGD group was significantly decreased（P〈0. 05）. The serum level of UA in middle and advanced PD patients was lower that in early patients（P〈0. 01）. The difference of the serum level of Cr between all cases was not statistically significant（P 〉0. 05）. Conclusions：The UA change may be involved in the pathogenesis of different motor subtypes of PD,which may be a potential useful biomarker in predicting risk,and diagnosing the severity and motor subtype of PD.

关 键 词：帕金森病 尿酸 运动亚型 

分 类 号：R742.5[医药卫生—神经病学与精神病学]