儿童食物蛋白诱导的小肠结肠炎综合征  

Food protein-induced enterocolitis syndrome in children

作　　者：吴捷[1] 陈云燕 

机构地区：[1]中国医科大学附属盛京医院小儿消化科,辽宁沈阳110004

出　　处：《中国实用儿科杂志》2017年第10期746-750,共5页Chinese Journal of Practical Pediatrics

摘　　要：食物蛋白诱导的小肠结肠炎综合征(FPIES)是由非lg E介导的胃肠道食物变态反应,目前发病机制尚不清楚。临床表现为反复剧烈呕吐、腹泻,急性FPIES会导致脱水、嗜睡,甚至休克,慢性FPIES主要表现为体重减轻和生长发育迟缓。该病主要累及婴幼儿,常见诱发FPIES的食物包括牛奶、大豆、大米、燕麦、鱼和蛋。诊断主要依赖于典型临床表现,以及回避可疑的食物蛋白后病情得到缓解,必要时需进行口服食物激发试验(OFC)以确诊或确定食物过敏来源。主要治疗方案为回避致敏食物和急性期的对症治疗。Food protein--induced enteroeolitis syndrome （FPIES） is a non-IgE mediated gastrointestinal allergic disorder, and the pathogenesis is still unknown. The clinical manifestations include repetitive severe vomiting and diarrhea. Acute FPIES can result in dehydration, lethargy and even shock. Chronic FPIES is mainly characterized by weight loss and growth retar- dation. FPIES mainly affects infants and toddlers. Common al- lergen includes milk, soybean, oats, fish and eggs. The diagno- sis is based on typical clinical manifestations and the fact that avoiding possible food source can alleviate the symptoms. If necessary, oral food challenge （OFC） is required to confirm the diagnosis or to find out the food allergy sources. The key treatment measures are to avoid allergen food and to carry out symptomatic treatment during acute phase.

关 键 词：小肠结肠炎 食物蛋白 儿童 

分 类 号：R72[医药卫生—儿科]