108例脑胶质瘤患者的预后影响因素分析  

Prognostic Factors Analysis of 108 Patients with Brain Glioma

作　　者：吕凤琼[1] 黄伟[2] 林爱国[3] 周忠惠[1] 梅丽华[1] 魏厚禄[3] 

机构地区：[1]遂宁市中心医院全科医学科,四川遂宁629000 [2]遂宁市中心医院脑外科,四川遂宁629000 [3]遂宁市第一人民医院脑外科,四川遂宁629000

出　　处：《肿瘤预防与治疗》2017年第5期359-363,共5页Journal of Cancer Control And Treatment

摘　　要：目的:分析脑胶质瘤患者的存活、预后的影响因素。方法:对本院2006~2014年手术治疗的108例脑胶质瘤患者进行回顾性分析,运用COX回归模型分析患者的性别、年龄、手术前的KPS评分、病理分级、是否完全切除肿瘤、术后放射治疗等因素对预后的影响。结果:全部患者1年、2年及3年生存率分别92%、84%、67%,中位生存时间49个月。全部患者的COX回归模型结果显示年龄、病理类型、KPS评分、放射治疗以及Ki-67及EGFR表达情况是患者生存的独立影响因素。病理高级别患者中,KPS评分、同步化疗为患者生存的独立影响因素。结论:中等年龄、低病理类型、高KPS评分、进行放疗以及Ki-67及EGFR低表达的胶质瘤患者生存情况较好,而高病理级别患者中,高KPS评分以及进行同步化疗的患者生存情况较好。Objective： To explore the related factors of survival and prognosis of brain glioma. Methods： 108 patients who have been confirmed with brain glioma during surgery from 2006 to 2014 were included for analysis retrospective- ly. The factors including sex, age, and Karnosky Performance Scale （KPS） score before surgery, surgical excision of part or all of the tumor, radiation treatment and so on were recorded. The COX regression was performed for the prognostic anal- ysis. Results： The 1-, 2- and 3- year survival rate was 92%, 84% and 67%, respectively; the median survival time was 49 months. The COX regression analysis showed age, pathological grading, KPS score, radiotherapy and the level of Ki- 67/EGFR were independently related to prognosis. In high pathological grading population, the result showed the KPS score and chemotherapy were the independently prognostic factors. Conclusion： Better prognostic glioma patients was de- pending on median age, low pathological grading, high KPS score, radiotherapy and low expression of Ki-67/EGFR. In the patients with high pathological grading, high KPS scores and chemotherapy were positively related to better survival out- come.

关 键 词：脑胶质瘤 预后因素 生存分析 

分 类 号：R739.41[医药卫生—肿瘤]