基于组织工程的内接触引导因子神经导管的制备设计及实施  

Preparation and Implementation of the Nerve Conduits with Contact Guidance Cues Based on Tissue Engineering

作　　者：戴光立[1] 钮心嘉[1] 尹俊[2] 

机构地区：[1]宁波市第一医院设备科,浙江宁波315010 [2]浙江大学,浙江杭州310000

出　　处：《医疗装备》2017年第19期28-30,共3页Medical Equipment

基　　金：国家自然科学基金青年项目<神经导管内壁纵向沟槽接触引导神经轴突生长的机理研究>(Grant No.11402056);宁波市自然科学基金项目;周围神经损伤修复中组织工程支架内接触引导因子的作用(项目号:2017A610215);课题主持人:戴光立

摘　　要：研究对象是新型周围神经损伤修复方法——神经导管方法。基于聚合物相变原理,通过干/湿纺丝法制备聚合物薄膜中空管,设计新型的喷丝头并搭建聚合物薄膜中空管的制备平台。制备新型聚合物神经导管,为通过引入接触引导因子而提高神经导管的修复效率提供新方法。This paper was focused on the fabrication of nerve conduits, which was a new method of nerve injury repair. In this paper, the polymeric hollow fiber membranes（HFMs） were fabricated using the phase inversion-based dry/wet spinning method. A novel spinneret with microstructured meddle was designed and a manufacturing platform of polymeric hollow fiber membranes was built. This work investigated the fabrication of novel polymeric nerve conduits, and provided a new method to improve the repair efficiency of nerve conduits by introducing the contact guidance cues to nerve conduits.

关 键 词：周围神经损伤 神经损伤修复 神经导管 物理接触引导因子 纺丝技术 聚合物薄膜中空管 内壁沟槽结构 

分 类 号：R318.08[医药卫生—生物医学工程]