胃神经内分泌癌临床病理特征及预后相关因素  

Clinicopathological characteristics and prognosis-related factors of gastric neuroendocrine carcinoma

作　　者：林晓琳[1] 许琦[1] 刘泽兵 孙荔[1] 肖秀英[1] 

机构地区：[1]上海交通大学医学院附属仁济医院肿瘤科,上海200127 [2]上海交通大学医学院附属仁济医院病理科,上海200127

出　　处：《肿瘤》2017年第10期1079-1085,共7页Tumor

基　　金：上海高校青年教师培养资助计划基金资助项目(编号:ZZjdyx13063)~~

摘　　要：目的 :探讨胃神经内分泌癌(gastric neuroendocrine carcinoma,G-NEC)的临床病理特征及预后相关因素。方法:回顾性分析2009年1月—2015年9月在上海交通大学医学院附属仁济医院接受手术治疗的46例G-NEC患者的临床病理资料;结合术前检查、手术情况、病理诊断、术后化疗和随访结果,对患者的临床病理特征及预后相关因素进行分析。结果:单因素分析结果显示,年龄、Borrmann分型、肿瘤TNM分期和M分期、Ki-67指数、手术根治情况、肝转移、血清癌胚抗原水平、术后化疗是G-NEC的预后相关因素(P值均<0.05)。多因素分析结果显示,年龄、手术根治情况、血清癌胚抗原水平、术后化疗是G-NEC预后的独立影响因素(P值均<0.05)。结论:G-NEC是一类高度恶性的少见肿瘤,预后差。手术是否根治、术后是否进行化疗以及血清癌胚抗原水平与G-NEC患者的预后密切相关。Objective： To investigate the clinicopathological characteristics and their relationship with the prognosis of gastric neuroendocrine carcinoma （G-NEC）. Methods： Medical records of 46 patients with G-NEC between January 2009 and September 2015 were reviewed to investigate the clinicopathological characteristics and their relationship with prognosis of G-NEC. Results： Univariate analysis showed that the factors including age, Borrmann classification, TNM stage, M stage, Ki-67 index, surgical approach, liver metastases, serum carcino-embryonic antigen （CEA） level and postoperative chemotherapy were related with the prognosis of G-NEC （all P 〈 0.05）. The multivariate analysis showed that the age, surgical approach, serum CEA level and postoperative chemotherapy were the independent prognostic factor of the prognosis （all P 〈 0.05）. Conclusion： G-NEC is a rare tumor with high degree of malignancy and poor prognosis. Patients with high serum CEA level have poor prognosis, and postoperative chemotherapy and surgical outcomes also affect the prognosis of G-NEC.

关 键 词：胃神经内分泌肿瘤 临床病理特征 手术 药物疗法 预后 

分 类 号：R735.3[医药卫生—肿瘤]