主动循环与单灌单抽腹腔热灌注化疗治疗卵巢癌腹腔积液的对比研究  

Active circulation vs single perfusion and single infusion for hyperthermic intraperitoneal chemotherapy in patients with peritoneal effusion of ovarian cancer

作　　者：王宝娜[1] 杨阳 苏佩佩 蒋纷纷 李梅[1] 

机构地区：[1]西安交通大学第二附属医院肿瘤科,陕西西安710004

出　　处：《肿瘤》2017年第10期1086-1091,共6页Tumor

摘　　要：目的 :比较主动循环与单灌单抽腹腔热灌注化疗治疗卵巢癌腹腔积液的疗效。方法 :将2016年3月—2017年5月接受主动循环腹腔热灌注化疗的53例卵巢癌腹腔积液患者作为研究组,2015年7月—2016年2月接受单灌单抽腹腔热灌注化疗的51例卵巢癌腹腔积液患者作为对照组。2组患者均接受紫杉醇联合顺铂方案化疗,每次治疗时进行3次热灌注,共治疗2个周期。比较2组灌注液进入腹腔和抽出腹腔时的温度、持续时间和治疗效果。结果 :2组灌注液进入腹腔的温度阈值均可控制为43.0~43.5℃。研究组灌注液出腹温度为41.0~41.5℃,且温度维持恒定。研究组患者腹腔积液治疗有效率为86.8%(46/53),对照组为64.7%(33/51),2组的差异有统计学意义(P<0.05)。除腹痛以外,2组不良反应发生率的差异无统计学意义(P值均>0.05)。结论:主动循环腹腔热灌注化疗治疗卵巢癌腹腔积液时的温度恒定、治疗时间短、安全性高且疗效显著,值得在临床上予以推广。Objective： To compare the efficacy between active circulation mode and single-irrigation and single-pumped mode for hyperthermic intraperitoneal perfusion in ovarian cancer patients with intraperitoneal effusion. Methods： Fifty-three ovarian cancer patients with intraperitoneal effusion treated with active circulation mode of hyperthermic intraperitoneal perfusion between March 2016 and May 2017 were taken as study group, and another 51 ovarian cancer patients with intraperitoneal effusion treated with single-irrigation and single- pumped mode of hyperthermic intraperitoneal perfusion between July 2015 and February 2016 were taken as control group. All of the patients received hyperthermic intraperitoneal chemotherapy with paclitaxel and cisplatin. Each treatment was administered 3 times and treated for 2 cycles. The temperature duration time of perfusion fluid into and out of the abdominal cavity and the response rate of two groups were compared. Results： The temperature threshold of perfusate into the abdominal cavity of two groups can be controlled between 43.0-43.5 ~C. The abdominal temperature of study group was 41.0-41.5 ~C and remained constant. The response rates of peritoneal effusion in study group and the control group were 86.8% （46/53） and 64.7% （33/51）, respectively; there was a significant difference between the two groups （P 〈 0.05）. Except for abdominal pain, the incidence rates of adverse reactions had no statistical differences （all P 〉 0.05）. Conclusion： Active circulation mode of hyperthermic intraperitoneal perfusion has the advantages of constant temperature, short treatment time, high safety and remarkable curative effect in the treatment of peritoneal effusion of ovarian cancer, and is worthy of promotion in clinical practice.

关 键 词：卵巢肿瘤 腹腔积液 体腔热灌注化疗 

分 类 号：R737.31[医药卫生—肿瘤]