RIZ1蛋白表达与宫颈鳞状细胞癌临床病理参数及放疗敏感性的相关性研究  

Relationship between expression of RIZ1 and clinicopathological factors or radiosensitivity in human cervical squamous cell carcinoma

作　　者：张云艳[1] 刘亚琴[1] 王磊[1] 张琳 成海燕[1] 杨姗姗[1] 

机构地区：[1]哈尔滨医科大学附属肿瘤医院,哈尔滨150081

出　　处：《实用肿瘤学杂志》2017年第5期405-410,共6页Practical Oncology Journal

基　　金：黑龙江省教育厅课题(12541371)

摘　　要：目的探讨宫颈鳞状细胞癌组织中Rb蛋白结合锌指结构基因1(RIZ1)的表达及其与宫颈癌患者临床病理参数及放疗敏感性的关系。方法采用免疫组化法观察RIZ1在159例宫颈鳞癌(Ⅱb、Ⅲa期)患者及20例正常宫颈组织中的表达情况,分析RIZ1在宫颈鳞癌组织中不同组间的差异表达情况,及其与宫颈癌放疗敏感性的相关性。结果与正常宫颈组织相比,RIZ1蛋白在宫颈鳞癌组织中的表达水平明显下降(P<0.001);RIZ1蛋白的表达水平与宫颈癌的放疗敏感性密切相关(P=0.012),并与FIGO分期(P=0.004)、深肌层浸润(P=0.026)、盆腔淋巴结转移(P=0.021)以及放疗后复发(P=0.005)密切相关,Logistic回归结果提示RIZ1蛋白高表达是宫颈癌放疗敏感性的独立预测因素(P=0.045)。结论 RIZ1可能参与宫颈鳞癌的发生与发展过程,并可能成为评估宫颈鳞癌放疗敏感性的候选标志物。Objective The aim of this study was to analyze the expression of RIZ1 and its association with clinicopathological factors or radiosensitivity in cervical squamous cell carcinoma. Methods 159 samples from patients with FIGO stage Ⅱ b and Ⅲ a cervical squamous cell carcinoma were collected and preserved before radiotherapy. The expression of RIZ1 in cervical squamous cell carcinoma tissues and 20 normal cervical tissues was assessed by immunohistochemistry. The relationship between the RIZ1 expression and the clinicopathological factors or radiosensitivity in cervical squamous cell carcinoma was analyzed by statistical analysis. Results The expression of RIZ1 protein was down-regulated in patients with cervical cancer（ P 0. 001）. The level of RIZ1 protein expression was close related to radiosensitivity（ P = 0. 012）,FIGO staging（ P = 0. 004）,deep myometrial invasion（ P = 0. 026）,and pelvic lymph node metastasis（ P = 0. 005）. Logistic regression analysis showed that the high expression of RIZ1 protein was an independent predictor of radiosensitivity in cervical cancer（ P =0. 045）. Conclusion RIZ1 may be involved in the occurrence and development process of cervical squamous cell carcinoma and regard as a candidate biomarker for the sensitivity in cervical squamous cell carcinoma in radiotherapy.

关 键 词：宫颈肿瘤 RIZ1 免疫组化 放疗敏感性 

分 类 号：R737.33[医药卫生—肿瘤]