复方降血脂丸质量标准研究  

Quality Standard of Fufang Jiangxuezhi Pills

作　　者：于士龙[1] 张汉道 程越 韩瑞贝 汪宇[1] 

机构地区：[1]中国人民解放军第四六三医院,辽宁沈阳110042 [2]中国人民解放军沈阳军区空军七〇五医院,辽宁沈阳110040 [3]沈阳药科大学,辽宁沈阳110046

出　　处：《中国药业》2017年第20期25-28,共4页China Pharmaceuticals

摘　　要：目的建立复方降血脂丸的质量标准。方法对方中丹参、决明子、何首乌、山楂等进行薄层色谱(TLC)鉴别;采用高效液相色谱(HPLC)法对方中君药决明子所含药效成分大黄酚进行含量测定。结果 TLC法斑点显色清晰,重复性、分离度均较好;大黄酚质量浓度在1.91~122.28μg/mL范围内与峰面积线性关系良好,r=0.999 6(n=7);平均加样回收率为108.01%,RSD为1.16%(n=6)。结论该研究中确立的定性、定量检测方法简便易行,重复性好,结果准确可靠,可用于复方降血脂丸的质量控制。Objective To establish the quality standard of Fufang Jiangxuezhi Pills. Methods TLC method was adopted for the qualitative identification of Salvia miltiorrhizae,Catsia tora,Fallopia multiflora and Crataegus pinnatifida. HPLC method was adopted to determine chrysophanol in Catsia tora. Results TLC spots were clear with good reproducibility and separation. The linear relationship of chrysophanol content was good in the range of 1. 91-122. 28 μg/mL,r=0. 9996 （ n=7）,the average recovery was 108. 01%,and the RSD was 1. 16%（n=6）. Conclusion The qualitative and quantitative method is simple,accurate and reliable,which can be used for quality control of Fufang Jiangxuezhi Pills.

关 键 词：复方降血脂丸 丹参 决明子 何首乌 山楂 大黄酚 薄层色谱鉴别法 高效液相色谱法 含量测定 质量标准 

分 类 号：R284.1[医药卫生—中药学] R285.5[医药卫生—中医学]