晚期NSCLC患者细胞块与配对组织块VEGF检测的对比研究  

Comparative Study of Cell Block and Paired Tissue Block VEGF in Patients With Advanced NSCLC

作　　者：张丽媛 黄琰[2] 李若葆[3] ZHANG Liyuan HUANG Yan LI Ruobao(School of Clinical Medicine, Weifang Medical University, Weifang Shandong 261041, China Oneology Department, The Affiliated Hospital of Weifang Medical University, Weifang Shandong 261041, China Department of Anatomy, Weifang Medical University, Weifang Shandong 261041, China)

机构地区：[1]潍坊医学院临床医学院,山东潍坊261041 [2]潍坊医学院附属医院肿瘤科,山东潍坊261041 [3]潍坊医学院解剖学教研室,山东潍坊261041

出　　处：《中国继续医学教育》2017年第23期54-55,共2页China Continuing Medical Education

基　　金：山东省医药卫生科技发展计划项目(2015WS0055)

摘　　要：目的探讨晚期非小细胞肺癌患者细胞学样本用于VEGF检测的临床价值。方法收集具有组织学对照的细胞学样本62例,采用Eli Vision法检测VEGF蛋白表达情况,分析比较细胞块与组织块的VEGF表达情况。结果组织块VEGF免疫组化阳性结果共24例,阳性率38.71%;细胞块VEGF免疫组化阳性结果共22例,阳性率35.48%;两组比较,差异不具有统计学意义(P=0.168>0.05)。结论胸水细胞块可代替组织学方法对晚期非小细胞肺癌进行VEGF筛查。ObjectiVe To investigate the clinical value of cytology samples for VEGF detection in advanced non-small cell lung cancer. Methods 62 samples of cytology with histological control were collected and the expression of VEGF protein was detected by EliVision. The expression of VEGF in cell block and tissue block was analyzed and compared. Results The positive results of VEGF immunohistochemical staining were 24 cases, the positive rate was 38.71%, the number of cell blocks was VEGF, and the positive results of immunohistochemistry were 22 cases, the positive rate was 35.48%. The difference between the two groups was not statistically significant （P=-0.168〉0.05）. Conclusion Pleural effusion blocks can be used for VEGF screening of advanced non-small cell lung cancer instead of histology.

关 键 词：肺腺癌 VEGF 胸水细胞块 免疫组化 

分 类 号：R734[医药卫生—肿瘤]