两种难溶性药物的输液调配规范  

Research on the Admixture Standard of Some Insoluble Drugs in PIVAS

作　　者：王超[1] 谭喜莹[1] 陈树[1] 刘秦 邰怡悦 徐韩 姚毅[1] WANG Chao TAN Xi-ying CHEN Shu LIU Qin TAI Yi-yue XU Han YAO Yi(Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing 210029 Nanjing University of Chi- nese Medicine, Nanjing 210023)

机构地区：[1]南京中医药大学附属医院,南京210029 [2]南京中医药大学药学院,南京210023

出　　处：《药学与临床研究》2017年第5期400-402,共3页Pharmaceutical and Clinical Research

基　　金：江苏省药学会-百特生物药学基金科研项目(201544)

摘　　要：考察静脉用药调配中心(PIVAS)两种难溶性药物输液中不溶性微粒与溶媒、振荡时间及调配方法之间的关系,建立其调配规范。通过光阻法测定环磷酰胺和表柔比星输液中不溶性微粒,探讨这两种药物的合理调配方法。通过实验得出最合理的调配方法,使输液中不溶微粒控制在合理范围之内,并兼顾调配效率。研究两种难溶性药物的合理调配方法,控制输液中的不溶微粒数,对保证输液的安全性和提高药师工作效率具有重要意义。To investigate the relationship among insoluble particles and solvent, oscillation time and admixture method of some drug products in PIVAS, then to establish insoluble drug admixture standard. A light blockage method was applied to test cyclophosphamide and epirubicin products for reasonable dispensing. The most reasonable method was found to control the insoluble particles in the transfusion within a reasonable range efficienctly. Rational dispensing of insoluble drugs is of great significance to ensure the safety of infusion products and improve the efficiency of team work.

关 键 词：不溶性微粒 难溶性药物 溶媒 振荡时间 光阻法 

分 类 号：R969.3[医药卫生—药理学] R942[医药卫生—药学]