γ干扰素释放试验在结核病筛查的价值评估  

Value evaluation on interferon-gamma release assays in screening of tuberculosis

作　　者：李宝辉[1] 赵光[1] 王道元 李冬晖[1] 

机构地区：[1]解放军150医院中心实验室,河南洛阳471031

出　　处：《实用医药杂志》2017年第10期892-895,共4页Practical Journal of Medicine & Pharmacy

摘　　要：目的探讨γ-干扰素释放试验(IGRA)在结核病筛查的价值并构建疾病归属预测模型。方法对613例疑似结核病例进行IGRA并构建检验库,与临床诊疗库比对分析。结果 NIFN-γ≥8.5及TIFN-γ-NIFN-γ≥14,96.2%患者为活动期结核,3.8%患者抗布氏杆菌治疗敏感;NIFN-γ<8.5及TIFN-γ-NIFN-γ≥400,73.9%患者为活动期结核,26.1%患者为陈旧性结核;NIFN-γ<8.5及14≤TIFN-γ-NIFN-γ<400,53.6%患者为活动期结核,36.4%患者为潜伏期结核,9.3%患者为陈旧性结核,0.7%患者抗布氏杆菌治疗敏感;TIFN-γ-NIFN-γ<14,2.8%患者抗结核治疗敏感。结论 IGRA在结核病筛查具有重要的意义,随着数据库病例的增加预测模型会更加准确可靠。Objective To explore the value of interferon-gamma release assays（IGRA） used in screening of tuberculosis （TB）,and to build its diagnostic model. Methods Comparing with their database of clinical diagnosis and treatments,authors enrolled 613 suspected tuberculosis patients and created database of IGRA laboratory diagnostics. Results NIFN-γ≥8.5 ＆ TIFN-γ-NIFN-γ≥14,96.2% was active TB,3.8% was sensitive to anti-Brucella therapy;NIFN-γ〈8.5 ＆ TIFN-γ-NIFN-γ≥400,73.9% was active TB,26.1% was old TB;NIFN-γ〈8.5 ＆ TIFN-γ-NIFN-γ≥400,53.6% was active TB,36.4% was latent TB,9.3% was old TB,0.7% was sensitive to anti-brucella therapy; TIEN-γ-NIFN-γ〈14,2.8% was sensitive to anti-TB therapy. Conclusion There is significant value of IGRA in screening tuberculosis,and with the rise of database ,the diagnostic model would be more accurate.

关 键 词：Γ-干扰素释放试验 结核病 诊断模型 

分 类 号：R730.43[医药卫生—肿瘤]