高表达miR-92a对结直肠癌患者预后影响的Meta分析  

A Meta-analysis of prognostic effect of elevated mir-92a in patients with colorectal cancer

作　　者：李利发 陈小波[1] 侯松林 刘带志 张广军[1,2] 周何[1] 周彤[1,2] LI Lifa CHEN Xiaobo HOU Songlin LIU Daizhi ZHA NG Guangjun ZHOU He ZHOU Tong(Department of Gastrointestinal Surgery, Affiliated Hospital of North Sichuan Medical College, Sichuan Province, Nanchong 637000, China Institute of Hepato-Biliary-Pancreas and Intestinal Disease, North Sichuan Medical College, Sichuan Province, Nachong 637000, China)

机构地区：[1]川北医学院附属医院胃肠外科,四川南充637000 [2]川北医学院肝胆胰肠研究所,四川南充637000

出　　处：《中国医药导报》2017年第29期15-18,68,共5页China Medical Herald

基　　金：四川省教育厅自然科学重点项目(14ZA0184)

摘　　要：目的系统评估mi R-92a对结直肠癌(CRC)患者病理生理特征及预后的影响。方法计算机检索Pub Med、中国生物医学数据库(CBM)、中国知网(CNKI)、万方数据库以及维普科技期刊数据库获取相关文献,检索时间从建库到2016年12月。利用stata 12.0对资料进行合并分析,数据采取危险比(HR),比值比(OR)以及95%置信区间(95%CI)表示。结果总共6篇文献,695例患者纳入本次Meta分析。合并分析表明:(1)高表达的mi R-92a与CRC患者总体生存率有着显著的联系(HR=2.91,95%CI:1.16~7.28,P<0.05);(2)高表达的mi R-92a与CRC患者肿瘤浸润深度(OR=0.56,95%CI:0.33~0.96,P<0.05),TNM分期(OR=0.41,95%CI:0.24~0.71,P<0.05),远处转移(OR=4.71,95%CI:1.74~12.69,P<0.05),淋巴结转移(OR=2.90,95%CI:1.64~5.13,P<0.05)有着明显的联系;与CRC患者的性别(OR=1.01,95%CI:0.60~1.69,P>0.05)和肿瘤分化程度(OR=0.66,95%CI:0.33~1.30,P>0.05)无明显关系。结论高表达的mi R-92a能够潜在的预测CRC患者总体预后和临床病理特征。Objective To systematically estimate the effect of over-expression miR-92a in clinicopathological and prognosis of patients with colorectal cancer. Methods All available literatures were obtained from PubMed, CBM, CN-KI, WanFaug, and Vip database,from the building up to December 2016. Eventually, the pooled hazard ratio （HR）, odds ratio （OR） and 95% confidence interval （95%CI） were evaluated by statistical software of stata 12.0. Results There were altogether 6 qualified articles with 695 patients in this Meta-analysis. The pooled analysis shows, ①which increased miR-92a levels were capable of predicting worse overall survival （HR=2.91, 95%CI： 1.16-7.28, P 〈 0.05） in CRC patients; ②which elevated miR-92a was distinctly associated with depth of tumor invasion （0R=0.56, 95%CI： 0.33-0.96, P 〈 0.05）, TNM stage （OR=0.41, 95%CI： 0.24-0.71, P 〈 0.05）, distant metastasis （OR=4.71, 95%CI： 1.74- 12.69, P 〈 0.05）, lymph node metastasis （OR=2.90, 95%CI： 1.64-5.13, P 〈 0.05）; however, high expression of miR-92a was negatively correlated with gender and tumor differentiation, with pooled OR of 1.01 （95%CI： 0.6-1.69, P 〉 0.05） and 0.66 （95% CI： 0.33-1.30, P 〉 0.05）, respectively. Conclusion Up-regulated miR-92a is able to predict survival outcomes and clinicopathologic features.

关 键 词：结直肠癌 MI R-92a 总体生存率 TNM分期 预后 META分析 

分 类 号：R73[医药卫生—肿瘤]