肝动脉化疗栓塞联合超声引导下微波消融治疗原发性肝癌的效果分析  

Effect of transcatheter arterial chemoembolization combined with ultrasound-guided microwave ablation in the treatment of primary hepatocellular carcinoma

作　　者：张猛[1] 高众[1] 谭贵芳[1] 刘智刚[1] 钱永[1] 张翼[1] ZHANG Meng GAO Zhong TAN Guifang LIU Zhigang QIAN Yong ZHANG Yi(Department of Intervention, Dalian Central Hospital, Liaoning Province, Dalian 116033, China)

机构地区：[1]辽宁省大连市中心医院介入科,辽宁大连116033

出　　处：《中国医药导报》2017年第29期103-106,共4页China Medical Herald

摘　　要：目的分析肝动脉化疗栓塞联合超声引导下微波消融治疗原发性肝癌的效果。方法选择2014年1月~2016年12月大连市中心医院收治的98例原发性肝癌患者为研究对象,根据治疗方式的不同,将患者分为观察组(50例)和对照组(48例)。对照组患者采用肝动脉化疗栓塞治疗,观察组患者采用肝动脉化疗栓塞联合超声引导下微波消融治疗。比较两组的治疗效果,治疗前及治疗后3个月检测两组患者的甲胎蛋白(AFP)、谷丙转氨酶(ALT)及谷草转氨酶(AST)水平,治疗过程中及治疗后观察两组患者不良反应发生情况。结果观察组患者治疗有效率及疾病控制率均高于对照组,差异有统计学意义(P<0.05);治疗后,两组AFP、ALT及AST水平均较本组治疗前明显降低,且观察组低于对照组,差异有统计学意义(P<0.05);两组患者治疗期间均发生了恶心、呕吐、腹泻、皮疹、骨髓抑制、发热、疼痛等并发症,两组各并发症发生率比较,但差异无统计学意义(P>0.05)。结论与单用肝动脉化疗栓塞治疗比较,肝动脉化疗栓塞联合超声引导下微波消融治疗,可明显提高效果,且不增加不良反应的发生,值得临床推广。Objective To analyze the effect of transcatheter arterial chemoembolization combined with ultrasound guid- ed microwave ablation in the treatment of primary liver cancer. Methods 98 patients with primary hepatocellular carcinoma treated in Dalian Central Hospital from January 2014 to December 2016 were selected as the study subjects. According to different treatment methods, patients were divided into observation group （50 cases） and control group （48 cases）. The patients in the control group were treated with hepatic artery chemoembolization, and the patients in the observation group were treated with transcatheter arterial chemoembolization combined with ultrasound guided microwave ablation. The treatment outcomes was compared between the two groups; before treatment and 3 months after treatment, the levels of alpha fetal protein （AFP）, glutamate aminotransferase （ALT） and glutamate transaminase （AST） of the patients in the two groups were tested; the adverse reactions in the two groups during and after treatment were observed. Results The total effective rate and disease control rate in the observation group were higher than those in the control group, with statistically significant difference（P 〈 0.05）; after treatment, levels of AFP, ALT and AST of the two groups were significantly lower than those before treatment, and the observation group was lower than that of the control group, with statistically significant difference （P 〈 0.05）. During treatment complications such as nausea, vomiting, diarrhea, skin rash, bone marrow suppression, fever, and pain happened in both groups, while the incidence of complications in the two group was not statistically different （P 〉 0.05）. Conclusion Compared with hepatic artery em- bolization chemotherapy alone, transcatheter arterial chemoembolization combined with ultrasound-guided percutaneous microwave ablation therapy can provide obvious therapeutic effect, and do not increase the occurrence of adverse reactions, which is worthy of

关 键 词：超声引导 肝动脉化疗栓塞 微波消融 原发性肝癌 效果 

分 类 号：R73[医药卫生—肿瘤]