蛛网膜下腔出血患者GFAP、S100B的表达与预后相关性研究  

Correlation between glial fibrillary acidic protein and S100B protein expression with prognosis in patients with subarachnoid hemorrhage

作　　者：郝芳芳 贺婕[1] 孙志华[1] 吴宝水[1] 肖丽萍[1] 

机构地区：[1]河北省廊坊市中国石油天然气集团公司中心医院神经内科,065000

出　　处：《检验医学与临床》2017年第20期3063-3065,共3页Laboratory Medicine and Clinic

摘　　要：目的测定珠网膜下腔出血(SAH)患者血清胶质纤维酸性蛋白(GFAP)、S100B蛋白表达水平,探讨其与SAH早期脑损伤及预后的相关性。方法选取该院2012年9月至2015年9月收治的SAH患者作为病例组,健康体检者为对照组,采用酶联免疫吸附实验检测SAH患者发病后1、2、3、6天血清GFAP和S100B蛋白表达水平,所有患者在相应时间点进行美国国立卫生研究院神经功能缺损评分,并于发病后6个月对以上患者进行格拉斯哥预后(GCS)评分。结果病例组发病后第1、2、3、6天血清GFAP、S100B水平与对照组比较差异有统计学意义(P<0.05),SAH后患者血清GFAP、S100B蛋白水平均与SAH早期脑损伤程度呈正相关性,与预后呈负相关性,差异均有统计学意义(P<0.05)。结论 SAH后血清GFAP、S100B表达水平可反映SAH早期脑损伤程度,为临床评估SAH早期脑损伤及预后提供依据。Objective To determine the levels of serum glial fibrillary acidic protein（GFAP）and S100 Bprotein in the patients with subarachnoid hemorrhage（SAH）,and to investigate their correlation with early brain injury and prognosis in SAH.MethodsThe SAH patients treated in the hospital from September 2012 to September 2015 were selected as the case group and the individuals undergoing physical examination served as the control group.The levels of serum GFAP and S100 Bprotein on 1,2,3,6dafter onset were detected by adopting the enzyme-linked immunosorbent assay.All cases were evaluated by using NIHSS at the corresponding time points.The cases of disease onset more than 6months were performed the GOS scoring.Results The levels of serum GFAP and S100 Bprotein on 1,2,3,6dafter onset had statistical difference between the case group and control group（P〈0.05）.The levels of serum GFAP and S100 Bprotein after SAH were positively correlated with early cerebral injury after SAH and negatively correlated with prognosis,the difference was statistically significant（P〈0.05）.Conclusion The expression levels of serum GFAP and S100 Bcan reflect the degree of early brain injury after SAH and provide a basis for the assessment of early brain injury after SAH and prognosis.

关 键 词：胶质纤维酸性蛋白 S100B蛋白 珠网膜下腔出血 早期脑损伤 

分 类 号：R743.34[医药卫生—神经病学与精神病学]