抗癌持久战:彻底治愈还是带癌生存  

The war against cancer: A complete cure or live with control?

作　　者：韩雅婷 王玺 HAN YaTing WANG Xi(Department of Cell Biology, School of Basic Medical Sciences, Tianjin Medical University, Tianjin 300070, Chin)

机构地区：[1]天津医科大学基础医学院细胞生物学系,天津300070

出　　处：《科学通报》2017年第28期3285-3289,共5页Chinese Science Bulletin

基　　金：中国博士后科学基金(2017M611174);天津医科大学科学基金(2015KYZQ01)资助

摘　　要：癌症种类众多,严重威胁着人类生命并极大程度上影响了患者的生活质量.随着对癌症研究的不断深入和科学技术的不断进步,癌症已从以前不可治愈的绝症转变为已有越来越多的癌症被治愈,说明治愈癌症是可能的.但是由于癌症本身的复杂性,目前还不能治愈所有的癌症,并且距离治愈所有的癌症还有很长路要走.因此随着知识的不断累积和治疗方法的不断完善,对癌症的控制程度也越来越高,最终一定能够解决这些问题,达到治愈癌症的目的.同时,在某些特定情况下,"带癌生存"也是一个现实的选择.Cancer is not one disease, but a collection of many diseases. It threatens patients＇ lives and reduces their life quality. As scientific research on cancer advances and technology improves, more and more cancers are being cured. For example, 70% cancers in children are cured. In adults, most types of skin cancer, thyroid cancer, laryngocarcinoma, testis carcinoma, Hodgkin lymphoma and some forms of leukemia are cured. This is largely due to the constantly improved and innovated treatments and therapies. Current treatments for cancer mainly include surgical therapy, chemistry therapy, radiation therapy, targeted therapy and immunotherapy. Immunotherapy is the most innovative one. After being treated with immunotherapy, patients with malignant melanoma, which was once believed to be incurable can now reach ten-year survival rate. This means ＂curing cancer＂ is possible. However, because of the complexity of cancer, no single method can prevent all cancers and no single treatment can cure all cancers. Most importantly, cancer cells can easily become resistant to current treatments. This resistance can arouse from environmental adaptation, tumor heterogeneous, and the physical position of cells within the tumor. Cancer cells in area where blood supply is poor may survive from treatments which require blood circulation to transport drugs or immune cells to target area for killing. Tumor heterogeneous means other than the fast dividing cancer cells in the tumor, there are also quiescent cells which do not respond to therapies aiming at dividing cells, and there may also present a small number of cells which originally bear resistance. Based on this original heterogeneity plus the different micro physical positions within the tumor, the diversity of the genome composition and the phenotype of these cancer cells are further increased. Under prolonged pressure from host, drug maintenance, host immune response and the non-permissive environment, most of the cancer cells may have been killed, but some cancer cells may

关 键 词：癌症 治愈 控制 抗性 

分 类 号：R730.5[医药卫生—肿瘤]