长链非编码RNA在前列腺癌早期诊断中的意义  

Significance of long non-coding RNA in early detection of prostate cancer

作　　者：唐勇泉 张若晨[1] 梁嘉宇 王玉杰[1] 卢一平[1] TANG Yongquan ZHANG Ruochen LIANG Jiayu WANG Yujie LU Yiping(Department of Urology/Urological Institute, West China Hospital, Siehuan University, Chengdu, 610041, China)

机构地区：[1]四川大学华西医院泌尿外科/泌尿外科研究所,成都610041

出　　处：《临床泌尿外科杂志》2017年第9期716-720,725,共6页Journal of Clinical Urology

基　　金：四川省科学技术厅项目基金(编号2014JY0183)

摘　　要：前列腺癌(PCa)在我国中老年男性人群中的发病率和死亡率都有升高的趋势。目前诊断前列腺癌的无创性检查有血清PSA、直肠前列腺指检、超声及MRI等,这些方法对前列腺癌早期诊断的效能都不高。长链非编码RNA(lnRNA)是基因转录产生的>200bpd的非氨基酸编码mRNA群体,被认为部分参与基因表达调控。有的lnRNA是前列腺癌细胞特异或相对特异的表达产物,被认为是潜在的诊断早期前列腺癌理想的生物标志。本文介绍了目前lnRNA在诊断前列腺癌方面的最新研究进展。Recently the morbidity and mortality of prostate cancer tended to rise in China.At present some non-invasive examinations including serum PSA,digital rectal examination,ultrasonography and MRI are used for the screening of prostate cancer,but the diagnostic performance was proved to be unideal.Long non-coding RNAs（lnRNAs）,〉200 bpd,are a series of non-protein-coding transcripts,and they are associated with the regulation of gene expression.Some lnRNAs are specific or relatively specific to prostate cancer,and they are regarded as ideal biomarkers to diagnose prostate cancer.This paper provided an introduction of the most recent reports about lnRNAs.

关 键 词：长链非编码RNA 前列腺癌 前列腺癌相关基因3 

分 类 号：R737.25[医药卫生—肿瘤]