参苓白术散对胃癌术后化疗生活质量及CD3^+和CD4^+的影响  

The effect of Shenlingbaizhu powder for improvement the CD3^+ and CD4^+ cell counts and quality of life in gastric cancer patients

作　　者：蔡照弟[1] CAI Zhao-di(Department of General Surgery, Shanghai University of Traditional Chinese Medicine, Affiliated Hospital of Yueyang Traditional Chinese and Western Medicine,Shanghai 200437, Chin)

机构地区：[1]上海中医药大学附属岳阳中西医结合医院普外科,上海200437

出　　处：《中国中西医结合消化杂志》2017年第9期675-677,共3页Chinese Journal of Integrated Traditional and Western Medicine on Digestion

摘　　要：[目的]观察参苓白术散对胃癌术后化疗患者生活质量及CD3^+和CD4^+细胞数量的影响。[方法]将75名胃癌患者随机分为治疗组(n=37)和对照组(n=38),治疗组在西医常规治疗的基础上予参苓白术散中药汤剂口服治疗,对照组采用西医常规治疗:手术+化疗。比较2组治疗前后QOL生活质量评分、CD3^+细胞数量和CD4^+细胞数量及II级以上毒副反应。[结果]2组治疗后的生活质量评分较治疗前有所升高(P<0.05),但是治疗组生活质量评分的改善程度较对照组高(P<0.05)。治疗组治疗前后CD3^+和CD4^+细胞数量差异有统计学意义(P<0.05),而对照组治疗前后CD3^+和CD4^+细胞数量差异无统计学意义(P>0.05),且治疗组治疗前后的CD3^+和CD4^+细胞数量的差值与对照组比较差异有统计学意义(P<0.05)。治疗组和对照组在白细胞下降、血小板、血红蛋白下降等II及以上的毒副反应差异无统计学意义(P>0.05)。在II级以上胃肠道毒副反应方面差异有统计学意义(P<0.05)。[结论]参苓白术散能有效的改善胃癌术后化疗患者的生活质量,提高患者CD3^+和CD4^+细胞数量,并且能降低化疗过程中出现的胃肠道不良反应。[Objective]To observe the effect of Shenlingbaizhu powder for improving the CD3~＋ and CD4~＋ cell counts and quality of life in gastric cancer patients.[Methods]75 patients with gastric cancer were randomly divided into treatment group（n=37）and control group（n=38）.The treatment group received Shenlingbaizhu Powder plus routine treatment,while the control group received routine treatment.The routine treatment inclued surgery and chemotherapy.The quality of life was assessed by the QOL scale before and after treatment.Besides,the CD3~＋ and CD4~＋ cell counts were compared between the two groups.And the side effect also was assessed during the treatment.[Results]The score of the QOL betweeen two groups were statisfically sigificant after the treatment（P〈0.05）,and the treatment group was higher than the control group（P〈0.05）.The difference in pre-/post-treatment of the CD3~＋ and CD4~＋ cell number was statistically significant differences between the treatment group and the control group（P〈0.05）.And the side effect of gastrointestinal reaction was lower in the treatment group than the control group（P〈0.05）.[Conclusion]The effect of Shenlingbaizhu Powder can not only improve the CD3~＋ and CD4~＋ cell counts,but also the qulity of life in gastric cancer patients.And it can help prevent the side effect of gastrointestinal reaction.

关 键 词：参苓白术散 胃癌 生活质量 CD3+ CD4+ 

分 类 号：R735[医药卫生—肿瘤]