血清DKK1及白细胞介素-6对肝细胞癌的诊断价值  

The diagnostic value of serum Dickkopf 1 and Interleukin-6 for hepatocellular carcinoma

作　　者：赵秀娟[1] 金大鹏[2] 张小云[1] 刘泽林[1] 孙向华[1] ZHAO Xiu-juan J IN Da-peng ZHANG Xiao-yun LIU Ze-lin SUN Xiang-hua(Department of Infections Disease, Langfang People＇ s Hospital, Hebei, Langfang 065000, China Department of Cardiology, Affiliated Hospital of Chengde Medical College, Hebei, Chengde 067000, China)

机构地区：[1]廊坊市人民医院感染科,河北廊坊065000 [2]承德医学院附属医院心脏内科,河北承德067000

出　　处：《中国中西医结合消化杂志》2017年第9期694-697,共4页Chinese Journal of Integrated Traditional and Western Medicine on Digestion

摘　　要：[目的]探讨血清Dickkopf-1(DKK1)及白细胞介素-6(interleukin-6,IL-6)对肝细胞癌的诊断价值。[方法]选取40例肝细胞癌患者、40例肝硬化患者、40例乙型病毒性肝炎患者、40例健康体检者,分别作为肝癌组、肝硬化组、肝炎组、对照组研究对象,利用ELISA方法,检测各组血清DKK1、IL-6、AFP水平,肝细胞癌患者病理参数与血清指标水平相关性,比较血清DKK1、IL-6、AFP对肝细胞癌的诊断效能。[结果]与对照组、肝炎组、肝硬化组比较,肝癌组患者血清DKK1、AFP水平明显增高,差异有统计学意义(P<0.05);与对照组及肝硬化组比较,肝癌患者血清IL-6水平明显增高,差异有统计学意义(P<0.05);肝细胞癌患者DKK1、IL-6、APF水平不因肿瘤数目、肿瘤大小、肿瘤分化程度等因素发生明显变化(P>0.05);但与Child-Pugh A级相比,Child-Pugh B级和C级患者IL-6、AFP水平明显增高(P<0.05);血清DKK1、IL-6及AFP对肝细胞癌检测的敏感度分别为50.0%(8/16)和43.8%(7/16),而联合检测敏感度为87.5%(14/16),与DKK1、IL-6及AFP检测比较,联合检测肝细胞癌的敏感度明显增高,差异有统计学意义(P<0.05)。[结论]血清DKK1及IL-6联合检测能够提高肝细胞癌的临床诊断率,值得临床广泛推广。[Objective]To study the diagnostic value of serum Dickkopf 1（DKK1） and interleukin-6（IL-6）for hepatocellular carcinoma.[Methods]40 cases of hepatocellular carcinoma,40 cases of liver cirrhosis,40 cases of hepatitis B virus infection and 40 cases of health examination were respectively regarded as the research subjects of liver cancer group,liver cirrhosis group,hepatitis group and control group.The serum levels of DKK1,IL-6 and AFP were detected by ELISA and compared its diagnostic efficacy for hepatocellular carcinoma.[Results]compared with control group,hepatitis group and liver cirrhosis group,the serum level of DKK1 and AFP were significantly increased in the liver cancer group with statistical difference（P〈0.05）;compared with the control group and liver cirrhosis group,the serum level of IL-6 was obviously increased in the liver cancer group with statistical difference（P〈0.05）;There were no obvious changes of DKK1,IL-6,AFP levels in hepatocellular carcinoma patients along tumor number,tumor size,tumor differentiation（P〈0.05）,but compared with the Child-Pugh A,the levels of IL-6 and AFP were significantly increased in Child-Pugh B^C patients（P〈0.05）;the sensitivity of hepatocellular carcinoma diagnosis by serum DKK1,IL-6 and AFP,DKK1 combined with IL-6 and AFP were respectively 50.0%（8/16）,43.8%（7/16）and 87.5%（14/16）.Compared with the single detection of DKK1 or IL-6 and AFP,the detection sensi-tivity of DKK1 combined with IL-6 and AFP for hepatocelluar carcinoma was significantly increased with statistical difference（P〈0.05）.[Conclusion]The serum detection of DKK1 combined with IL-6 can signficantly increase the clinical diagnosis rate of hepatocellular carcinoma and is worhty of clinical promotion.

关 键 词：DKK1 IL-6 AFP 肝细胞癌 

分 类 号：R735.7[医药卫生—肿瘤]