外周血白细胞与急性缺血性卒中的相关性研究  

Correlation of leukocyte counts in the peripheral blood with acute ischemic stroke

作　　者：栗静[1] 田婷[1] 石正洪[1] 冯斌[1] 

机构地区：[1]兰州大学第二医院神经内科,兰州730000

出　　处：《中国实用神经疾病杂志》2017年第6期1-5,共5页Chinese Journal of Practical Nervous Diseases

基　　金：兰州科技计划项目(No.2011-1-134);兰州市2015年第二批科技计划项目(No.2015-2-57)

摘　　要：目的探讨外周血早期白细胞及其亚型与急性缺血性卒中(AIS)发生、发展的关系。方法连续收集AIS住院患者588例,性别和年龄匹配的非脑卒中患者630例,比较2组患者的临床资料并进行多元Logistic回归分析。根据头颅CT或MRI梗死面积大小将AIS患者分为腔隙性AIS组151例和非腔隙性AIS组437例,比较2组白细胞参数并进行多元Logistic回归分析。结果 AIS组白细胞、中性粒细胞及中性粒细胞/淋巴细胞比值(NLR)高于对照组,差异有统计学意义(P<0.05);Logistic回归分析显示,白细胞计数(OR=1.073,95%CI:1.017~1.132,P=0.009)和中性粒细胞计数(OR=1.068,95%CI:1.001~1.139,P=0.046)进入回归方程。非腔隙性AIS组白细胞计数高于腔隙性AIS组,差异有统计学意义(P<0.05);Logistic回归分析显示,白细胞计数(OR=0.898,95%CI:0.811~0.995,P=0.040)进入回归方程。结论白细胞和中性粒细胞升高是AIS的独立危险因素,低白细胞计数为腔隙性AIS的危险因素,白细胞计数对AIS的发生及梗死面积具有一定的预测价值。Objective To investigate the relationship between the early leukocyte counts and its subtypes in the peripheral blood with the incidence and development of acute ischemic stroke(AIS).Methods A total of 588 patients with AIS and 630 patients free of stroke matched with gender and age were recruited in this study.The clinical data of the two groups were compared and the multi-factor Logistic regression was used.AIS patients were divided into lacunar AIS group(n=151)and non-lacunar AIS group(n=437)according to infarction size scanned by CT or MRI.The related leukocyte parameters of the two groups were compared and the multi-factor Logistic regression was used.Results The leukocyte counts,neutrophil counts and neutrophil to lymphocyte ratio(NLR)in the AIS group were higher than those in the control group(P <0.05);the Logistic regression analysis showed that the leukocyte counts(OR=1.073,95% CI:1.017~1.132,P=0.009)and neutrophil counts(OR=1.068,95% CI:1.001~1.139,P=0.046)entered the regression equation.Compared with the lacunar AIS group,the leukocyte counts of the nonlacunar AIS group was higher,with a statistically significant difference(P<0.05);the Logistic regression analysis showed that the leukocyte counts(OR=0.898,95% CI:0.811~0.995,P=0.040)entered the regression equation.Conclusion The elevated leukocyte and neutrophil counts are independent risk factors for AIS,and the low leukocyte counts is independent risk factor for lacunar AIS.So the leukocyte counts has a certain predictive value in the incidence and infarction volume of AIS.

关 键 词：脑卒中 梗死面积 白细胞 中性粒细胞 中性粒细胞/淋巴细胞比值 

分 类 号：R743.33[医药卫生—神经病学与精神病学]