抑郁症与血清低密度脂蛋白关系的Meta分析  

Depression and serum low-density lipoprotein Meta-analysis

作　　者：吕必华[1] 龚玉莎 叶方立[2] 

机构地区：[1]武汉大学中南医院,武汉430071 [2]武汉科技大学公共卫生学院

出　　处：《公共卫生与预防医学》2017年第5期87-89,共3页Journal of Public Health and Preventive Medicine

摘　　要：目的探讨血清低密度脂蛋白(LDL)与抑郁症之间的关系,为抑郁症发病的病理生理机制提供证据。方法检索Pub Med,Elsevier,CNKI数据库有关LDL与抑郁症发病风险之间联系的研究,提取效应值进行统计分析。结果抑郁症患者血清LDL水平未见显著降低,其标准均差Standardized Mean Difference(SMD)=-0.15(-0.67,0.37);按亚组分析显示,中低收入患者和男性患者的血清LDL水平下降,其SMD分别为-1.08(-1.80,-0.35)和-1.31(-2.61,-0.00),结果差异有统计学意义(P<0.05)。结论抑郁症总体血清LDL水平未见显著降低,但在收入水平和性别方面血清LDL可能与抑郁症存在联系。Objective This study aimed to clarify the relationship between depression and serum LDL to provide evidence for the physiological mechanism of depression. Methods Published articles were collected from Medline, Elsevier, Springer and CNKI database to extract the necessary data and conduct statistics analysis. Results There was no significant decrease in serum LDL in depression [Standardized Mean Difference （SMD） = -0. 15（ -0.67,0.37） ] ;but according to the sub-analysis,it showed that lower serum LDL existed in the low-income [ SMD =-1.08（ -1.8, -0. 35）] and male sub-group [ SMD = - 1.31 （ - 2. 61, -0.00）] with statistical significance（ P 〈 0. 05 ） . Conclusion The overall serum LDL level was not significantly lower in depression, however, there might be a link between depression with low serum LDL in terms of gender or income level group.

关 键 词：低密度脂蛋白 血脂 胆固醇 抑郁症 META分析 

分 类 号：R749.4[医药卫生—神经病学与精神病学]