青年脑梗死发病和复发危险因素相关分析  

The Correlations Analysis of Related Risk Factors with Morbidity and Recurrence of Cerebral Infarction in Young Patients

作　　者：陈建军[1] 梅志忠[1] 林菡[1] 官少兵[1] 方浩威[1] 余映丽[1] 

机构地区：[1]广东省东莞市厚街医院神经内科,523945

出　　处：《岭南急诊医学杂志》2017年第3期237-239,共3页Lingnan Journal of Emergency Medicine

基　　金：广东省东莞市科技计划项目(20131051010159)

摘　　要：目的:探讨青年脑梗死患者发病和复发与危险因素的相关性。方法:18-45岁脑梗死患者226例,采用NIHSS评估患者神经功能缺损程度,按病因进行TOAST分类。选取糖尿病、高血压、脂代谢异常、吸烟、饮酒、房颤、房扑、心肌梗死、心脏附壁血栓等危险因素为研究内容。采用Spearman等级相关分析评价NIHSS分级与TOAST分类之间的关系;采用logistic回归分析评价青年脑梗死复发与危险因素的相关性。结果:脑梗死复发14例,男11例(6.4%),女3例(5.6%)。NIHSS分级中轻度为主(75.2%)。而TOAST分类中,大动脉粥样硬化性脑卒中最多(47.8%),不明原因者19.5%。NIHSS分级与TOAST分类无关(P=0.96);糖尿病和高血压与青年脑梗死发病和复发相关(分别为P=0.042,OR=3.91,95%CI 1.12-14.24;P=0.047,OR=4.21,95%CI 1.12-14.24)。结论:在青年脑梗死发病和复发的危险因素中,糖尿病和高血压有显著相关性。Objective： To explore the correlation between the related risk factors and the morbidity and recurrence of cerebral infarction in young patients. Methods：226 young patients with cerebral infarction were involved in the study,whose age were between 18 to 45 years old. The degree of nerve function defect of patients were evaluated by the National Institutes of Health Stroke Scale（NIHSS）,and the etiology classification were classified by TOAST. The related risk factors such as diabetes,hypertension,lipid metabolism disorders,smoking,drinking,atrial fibrillation and flutter,myocardial infarction,mural thrombus were selected. The relationship between NIHSS grading and the TOAST classification was evaluated by the Spearman rank correlation analysis and the correlations between the risk factors and morbidity and recurrence of cerebral infarction in young patients were analyzed by the logistic regression analysis. Results：The recurrence of cerebral infarction in young patients was 14 cases,of which male was 11 cases with recurrence rate of 6.4%,and female was 3 cases with recurrence rate of 5.6%.The low grade of NIHSS was accounted for75.2%. In TOAST classification,the large atherosclerotic stroke（47.8%）was the most prevalent,followed by unknown reason（19.5%）. There was no correlation between NIHSS and TOAST（P=0.96）. Diabetes and hypertension were the risk factors of recurrence of cerebral infarction in young patients（respectively are P=0.042,OR=3.91,95% CI 1.12-14.24;P=0.047,OR=4.21,95% CI 1.12-14.24）. Conclusion：Diabetes and hypertension have a significant correlation with morbidity and recurrence of cerebral infarction in young patients.

关 键 词：青年 脑梗死 复发 危险因素 

分 类 号：R743.3[医药卫生—神经病学与精神病学]