四羟基壬烯的表达及其在前列腺癌雄激素拮抗中的作用  

The role of 4-hydroxynonenal expression in androgen antagonism of prostate cancer

作　　者：宋旭[1] 王蓉[1] 肖锋[2] 张圣熙[1] 龚敏[1] 王秀玲[2] 张耘[1] 黄锦阳[1] 

机构地区：[1]上海市第七人民医院泌尿外科,上海200137 [2]上海市第七人民医院病理科,上海200137

出　　处：《国际泌尿系统杂志》2017年第5期641-643,共3页International Journal of Urology and Nephrology

基　　金：上海市浦东新区卫生系统重点专科建设基金资助（PWZz2013-16）;上海市卫生和计划生育委员会科研课题基金资助（201440545）

摘　　要：目的 探讨四羟基壬烯（4-hydroxynonenal,4-HNE）的表达及其在前列腺癌雄激素拮抗中的作用.方法 采用免疫组织化学方法检测40例前列腺癌组织及42例前列腺增生组织中4-HNE的表达情况,分析4-HNE的表达与肿瘤进展性的关系.结果 4-HNE在42例前列腺增生组织中阳性表达率较低,仅为4.8％.40例前列腺癌组织中4-HNE高表达,去势抵抗性前列腺癌阳性率评分明显高于非去势抵抗性前列腺癌,差异有统计学意义（P＜0.01）.结论 4-HNE的高表达,可能在前列腺癌的进展和雄激素拮抗中起重要作用.Objective To investigate the 4-hydroxynonenal （4-HNE） expression and its role in androgen antagonism of prostate cancer.Methods Immunohistochemistry was used to detect the expression of 4-HNE of 40 cases of prostate cancer and 42 cases of benign prostatic hyperplasia,and the relationship between 4-HNE expression of tumor progression was analyzed.Results The expression of 4-HNE in 42 cases of benign prostatic hyperplasia was low,only 5.0％.4-HNE in prostate hyperplasia showed high level.By positive expression of ratings analysis,positive rate of castration resistant prostate cancer was significantly higher than non-castration-resistant prostate cancer,the difference was statistically significant （P ＜ 0.01）.Conclusions The expression of 4-HNE may play an important role in androgen antagonism and the progression of prostate cancer.

关 键 词：前列腺肿瘤 雄激素类 

分 类 号：R737.25[医药卫生—肿瘤]