肿瘤来源的外泌体在胃癌中的研究进展  

Tumor-derived exosomes in gastric cancer

作　　者：顾俊菁 胡林[1] 李红浪[1] 

机构地区：[1]南昌大学第二附属医院胃肠外科,江西省南昌市330006

出　　处：《世界华人消化杂志》2017年第26期2366-2371,共6页World Chinese Journal of Digestology

摘　　要：外泌体是一种由各种细胞分泌的直径在30-100 nm的胞外囊泡,这些囊泡能通过传递其内容物给受体细胞,从而产生相应的作用.胃癌是消化系常见恶性肿瘤之一,发病率和死亡率都很高.越来越多的证据表明外泌体在胃癌的生物学行为中起着关键作用,该综述就胃癌领域肿瘤发生、增殖、复发、转移、免疫逃避、耐药、早期诊断、生物治疗等方面进行了系统性的回顾,探讨了其用于胃癌治疗、标志物检测等方面的潜能.Exosomes are extracellular vesicles with a diameter of 30-100 nm secreted by various cells, which can exert diverse effects by transferring their contents to the recipient cells. Gastric cancer is one of the common malignant tumors of the digestive system, with high morbidity and mortality. There is growing evidence that exosomes play a key role in the biological behavior of gastric cancer. This review describes the role of tumor-derived exosomes in the tumorigenesis, proliferation, recurrence, metastasis, immune escape, drug resistance, early diagnosis, and biotherapy in gastric cancer, and discusses their potential use in marker detection and treatment in this malignancy.

关 键 词：外泌体 胃癌 早期诊断 生物治疗 

分 类 号：R735.2[医药卫生—肿瘤]