肝脏纤维化指数对原发性肝癌患者术后生存状况的影响  

Impact of liver fibrosis index on postoperative living conditions of patients with primary liver cancer

作　　者：刘溪涛[1] 仝林虎[1] 刘立业[1] 

机构地区：[1]内蒙古医科大学附属医院肝胆胰腺外科,呼和浩特010059

出　　处：《中华普外科手术学杂志（电子版）》2017年第5期390-392,共3页Chinese Journal of Operative Procedures of General Surgery(Electronic Edition)

摘　　要：目的探讨肝脏纤维化指数对原发性肝癌患者外科治疗后生存状况的影响。方法对2009年7月至2011年10月行肝切除的76例肝癌患者资料进行回顾性分析,根据手术前肝纤维化指数的高低将患者分为高指数组(40例)及低指数组(36例)。采用SPSS 21.0统计软件进行统计分析。患者肿瘤复发情况,生存率用卡方检验;平均生存期用均数±标准差表示,使用t检验;生存分析和比较用log rank法进行单因素分析,以P<0.05视为差异有统计学意义。结果两组患者分别在肿瘤数目、最大肿瘤直径、血管侵犯情况、静脉栓塞情况及切缘阳性情况上,低指数组均低于高指数组,差异有统计学意义(P<0.05);低指数组患者复发率为16.7%显著低于高指数组67.5%;低指数组患者生存时间(44.2±12.3)个月长于高指数组(21.3±8.7)个月;低指数组患者1、3、5年的生存率分别为94.4%、52.8%及47.2%均显著高于高指数组的72.5%、42.5%及22.5%,差异均有统计学意义(P<0.05);回归分析显示:肝纤维化指数、甲胎蛋白含量及术前肿瘤数是肝癌手术后复发的独立危险因素(P<0.05)。结论肝纤维化指数对于行肝切除术的肝癌患者的预后具有一定预测意义,可以在临床推广使用。Objective To explore the impact of liver fibrosis index on postoperative living conditions of patients with primary liver cancer. Methods From July 2009 to October 2011, clinical data of 76 cases with liver cancer who received liver resection were analyzed .According to the patients＇FI, 40 patients were divided into high index group and 36 cases into low index group.SPSS 21.0 statistical software was used for statistical analysis.Chi square test was used to analyze the survival rate .T-test was used to analyze the average survival period.Survival analysis and comparison with the log rank method was used for univariate analysis.A P value 〈0.05 was considered as statistically significant difference . Results Compared with high index group, there was less tumors, vascular invasion, venous thromboembolism and positive margin situation in low index group.（P 〈0.05）.Recurrence rate of low index group （16.7%） was significantly lower than that of high index group （67.5%） and the survival time was significantly longer （P 〈0.05）. The 1 /3/5 years survival rate in low index group were 94.4%, 52.8% and 47.2% respectively, which were significantly higher than 72.5%, 42.5% and 22.5% in high index group （ P 〈0.05）.The regression analysis showed that the protein content , postoperative hepatic fibrosis index , AFP was the independent risk factors of recurrence of hepatocellular carcinoma after operation （P 〈0.05）. Conclusion The index of liver fibrosis has certain predictive significance for the prognosis of patients with liver cancer after hepatectomy.

关 键 词：肝硬化 癌 肝细胞 肝切除术 预后 

分 类 号：R735.7[医药卫生—肿瘤]