MR-DWI在肝硬化背景下肝细胞癌临床诊断中的应用  

The application of MR-DWI in clinical diagnosis of hepatocellular carcinoma in cirrhosis liver

作　　者：张静[1,2] 姜庆军 孙钢[3] 尹勇[2] 

机构地区：[1]山东师范大学物理与电子科学学院,山东济南250358 [2]山东大学附属山东省肿瘤医院放射物理技术科,山东济南250117 [3]济南军区总医院医学影像科,山东济南250031

出　　处：《医学影像学杂志》2017年第10期2010-2014,共5页Journal of Medical Imaging

基　　金：国家自然科学基金(编号:81472811;81301936);山东省科技发展计划项目(编号:2014GSF118011)

摘　　要：近年随着医学影像技术的发展,肝硬化背景下肝癌患者局灶性病变的检出率得到了很大的提升,但对小病灶的敏感性仍然较低。小肝癌早期表现常不典型,易与肝硬化良性结节混淆。MR的弥散加权成像(DWI)技术能从分子水平检测水分子活动受限情况,在肝细胞肝癌(HCC)诊断中能反映因癌变而产生的水分子信号变化,而表观扩散系数(ADC)可描述不同方向的分子扩散运动的速度和范围,有助于定量分析病灶性质。本文就肝硬化HCC的DWI-ADC成像因素及其在诊断、分化以及预后评估中的应用进行综述。With the development of medical imaging,the diagnostic accuracy for focal lesions of hepatocellular carcinoma in cirrhosis has been greatly improved,but the sensitivity for tumors smaller than 2 cm is still very low. Small hepatocellular carcinoma in early stage is often atypical,and can be easily confused with benign nodules of liver cirrhosis. MRI diffusion weighted imaging（ DWI） can detect the restriction of water molecules activation from the molecular level,reflecting the signal of water molecules caused by cancer in hepatocellular carcinoma（ HCC）. And the apparent diffusion coefficient（ ADC） can describe the speed and scope of molecular diffusion movement in different directions,helping to quantitative analysis of the nature of the lesion. This article reviews the application of DWI-ADC in the diagnosis,and assessment of staging,prognostication of HCC in liver cirrhosis.

关 键 词：磁共振成像 肝硬化 肝细胞癌 

分 类 号：R735.7[医药卫生—肿瘤] R445.2[医药卫生—临床医学]