电子支气管镜智能分光比色技术对中央型肺癌诊断价值探讨  

Diagnostic value of electronic bronchoscopy intelligent spectroscopic colorimetric technique in central type lung carcinoma

作　　者：黄洁丽[1] 周航[1] 王江红[1,2] 

机构地区：[1]重庆市肿瘤研究所/医院/癌症中心内镜治疗中心,400030 [2]广西医科大学研究生学院,南宁530021

出　　处：《重庆医学》2017年第30期4177-4180,共4页Chongqing medicine

基　　金：重庆市社会事业与民生保障科技创新专项(cstc2015shmszx10022)

摘　　要：目的研究智能分光比色技术(FICE)对中央型肺癌的观察效果,选出最佳波长组合,探讨FICE对中央型支气管肺癌的诊断价值。方法 2016年1-10月在重庆市肿瘤医院进行支气管镜检查,资料保存完整,有明确病理组织学诊断的患者146例纳入研究。分别用白光支气管镜(WLB)及FICE观察,FICE 10组波长组合分别对毛细血管形态进行评分,选出最佳波长组合,分别钳取活检,最终以病理结果作为金标准对比研究。结果 FICE 10组波长组合对病灶观察效果差异有统计学意义(P<0.01),波长组合8[红(R)=540(2)、绿(G)=505(4)、蓝(B)=420(5),波长(nm,增益值)]在观察病灶血管纹理方面优于其他波长组合(Rank%=9.74)。FICE对病灶性质的判断准确率为88.4%,结合WLB对中央型肺癌的检出率为96.6%,与单独WLB比较,检出率差异有统计学意义(P<0.01)。结论 FICE波长组合8[R=540(2)、G=505(4)、B=420(5),波长(nm,增益值)]对观察中央型肺癌病变组织的黏膜浅表毛细血管形态效果较为理想。Objective To investigate the observation effect of Fuji intelligent chromoendoscopy（FICE）in central type lung cancer,to select the optimal wavelength combination and to explore its diagnostic value for central type bronchogenic lung carcinoma.Methods One hundred and forty-six cases of definite histopathological diagnosis by bronchoscopy examination with preserved intact data in the Chongqing Municipal Tumor Hospital from January 2016 to October 2016 were included into this study.The white light bronchoscopy（WLB）and FICE were used to conduct the observation respectively.The capillary morphology was respectively scored by using the 10 wave combinations in FICE.The best wave combination was selected for conducting the forceps biopsy.Finally the pathological results served as the gold standard for conducting the comparative study.Results The difference of lesion observation effect among 10 sets of FICE wave combination had statistical significance（P〈0.01）,the wave combination 8 [R=540（2）,G=505（4）,B=420（5）,wavelegnth（nm gain value）]was superior to that of other wave combinations in observing lesion vascular texture（Rank%=9.74）.The coincidence rate of FICE for judging the lesion property was 88.4%.The detection rate of FICE combined with WLB for central type lung cancer was 96.6%,compared with that of single WLB,the detection rate had statistically significant difference（P〈0.01）.Conclusion FICE wave combination 8 [R=540（2）,G=505（4）,B=420（5）,wavelength（nm,gain value）]is most ideal for observing superficial mucosal capillary vascular morphology of central type lung cancer lesion tissue.

关 键 词：比色法 肺肿瘤 支气管镜 智能分光比色技术 中央型肺癌 

分 类 号：R734.2[医药卫生—肿瘤]