蛇毒抗肿瘤应用及其机制的研究进展  

Advances in the research on application and antitumor mechanism of snake venom

作　　者：黄秒[1] 胡启平 Miao HUANG Qiping HU(Radiology Department, Affiliated Tumor Hospital Guangxi Medical University, Nanning 530021, China Department of Cell Biology and Genetics, School of Pre-clinical Medicine, Guangxi Medical University, Nanning 530021, China)

机构地区：[1]广西医科大学附属肿瘤医院影像学诊断中心,南宁市530021 [2]广西医科大学基础医学院细胞生物学与遗传学教研室

出　　处：《中国肿瘤临床》2017年第19期988-992,共5页Chinese Journal of Clinical Oncology

基　　金：广西卫生厅项目(编号:Z2015602);广西自然科学基金项目(编号:2014GXNSFAA118172)资助~~

摘　　要：蛇毒对多种恶性肿瘤细胞有抑制增殖、诱导细胞凋亡和(或)抑制细胞迁移等作用,且呈剂量效应和(或)时间效应关系;此外,蛇毒还具有抗肿瘤血管生成作用。蛇毒抗肿瘤机制如下:1)通过阻断某些信号通路抑制肿瘤转移;2)通过激活死亡信号通路诱导肿瘤细胞凋亡;3)通过调节抑(促)癌基因表达或阻滞细胞周期抑制肿瘤细胞生长和增殖;4)通过抑制肿瘤细胞表达血管内皮生长因子(vascular endothelial growth factor,VEGF)而抑制肿瘤血管生成。蛇毒在抗肿瘤应用方面具有较大的发展空间。本文对近年来国内外蛇毒抗肿瘤应用相关文献资料进行整理和归纳,总结了蛇毒抗肿瘤作用及其机制,以期为蛇毒抗肿瘤成分的研究、开发和应用提供参考。Recent literatures on antitumor effect, mechanism, and application of snake venom were summarized. This study aimed to provide a basis for the research, development, and application of snake venom which includes antitumor components. The abilities of snake venom was found in inhibiting tumor proliferation and migration and/or inducing apoptosis in a variety of malignant tumor cells at dose-dependent and/or time-dependent manner. Some types of snake venom inhibit tumoral angiogenesis. Meanwhile, the antitumor mechanisms of snake venom were as follows： 1） inhibit tumor metastasis by blocking certain signaling pathways, 2） induce apoptosis of tumor cells by activating the death pathway, 3） inhibit growth and proliferation of tumor cells by regulating the expression of tumor suppressor（promoter） genes or arresting the cell cycle, and 4） inhibit tumoral angiogenesis by inhibiting the expression of VEGF from cancer cells. Thus, snake venom has potential as an antitumor agent.

关 键 词：蛇毒 抗肿瘤 机制 增殖 迁移 凋亡 血管生成 

分 类 号：R73-36[医药卫生—肿瘤]