Preliminary evidence that overexpression of nuclearfactor for IL6 expression (NF-IL6) in NIH3T3 cells may berelated to malignant transformation  

作　　者：ZHU MINSHENG DINGGAN LIU SHIZUO AKIRA ZAIPING LI.(Shanghai Institute of Biochemistry, Academic Sinica,Shanghai 200031, China)(Institute of Molecular and Cellular Biology, Osaka University, Japan) 

出　　处：《Cell Research》1994年第2期191-200,共10页细胞研究（英文版）

摘　　要：NF-IL6 is a member of c/EBP family and has multiple functions in regulation of cellular gene expression. We have constructed NF-IL6 expression plasmids and trans fected the NIH3T3 cells with them. The sense NF-IL6 transfectants showed significantly increased tumorigenicity, and the stable integration of NF-IL6 cDNA into cellular DNA and its expression were demonstrated. Our results suggest that NF-IL6 may be related to tumorigenesis.

关 键 词：NF-IL6 NIH3T3 tumorigenicity 

分 类 号：R730.2[医药卫生—肿瘤]