小牛脾提取物对卵巢上皮性恶性肿瘤术后化疗患者的疗效及对MMP-2和CA125的影响  

Efficacy of Calf Spleen Extractive for Patients with Ovarian Epithelial Malignant Tumor Treated with Postoperative Chemotherapy and Its Effect on MMP-2 and CA125

作　　者：王军伟[1] 张静[1] 刘晓英[1] 陈江[2] 

机构地区：[1]陕西省人民医院,710068 [2]武警陕西总队医院,710054

出　　处：《实用癌症杂志》2017年第11期1780-1783,共4页The Practical Journal of Cancer

摘　　要：目的探讨小牛脾提取物对卵巢上皮性恶性肿瘤术后化疗患者的疗效及对血清中金属蛋白酶(MMP)-2和糖蛋白抗原125(CA125)的影响。方法将88例卵巢上皮性恶性肿瘤患者随机分为对照组44例和治疗组44例。对照组采取手术联合术后化疗。治疗组在对照组基础上予小牛脾提取物注射液,1次/d,10 m L/次,连续8周。比较两组生活质量、不良反应及血清中MMP-2及CA125水平。结果治疗组化疗后8周疼痛、恶心呕吐、疲倦评分明显低于对照组,躯体功能、角色功能、认知功能、情绪功能及社会功能评分显著高于对照组(P<0.01)。治疗组白细胞减少、恶心呕吐及肝肾功能损伤发生率显著低于对照组(P<0.05),两组神经毒性发生率比较无统计学意义(P>0.05)。化疗后8周,治疗组血清中MMP-2和CA125水平明显低于对照组(P<0.01)。结论小牛脾提取物可明显改善恶性卵巢肿瘤术后化疗患者的生活质量,降低不良反应,抑制患者血清中MMP-2和CA125水平可能与其疗效有关。Objective To investigate the efficacy of calf spleen extractive for patients with ovarian epithelial malignant tumor treated with postoperative chemotherapy and its influence on serum levels of MMP-2 and CA125. Methods 88 cases with ovarian epithelial malignant tumor were randomly divided into the control group and the treatment group, with 44 cases in each group. The control group was given with routine chemotherapy after operation. Based on the control group, the treatment group re- ceived calf spleen extractive injection by intravenous drip, ltime/d, and 10mL/time for 8 weeks. Life quality and occurrence rate of adverse reactions were compared between the 2 groups. Serum levels of MMP-2 and CA125 were detected in the 2 groups. Resuits 8 weeks after chemotherapy, scores of pain, vomiting, and fatigue of treatment were obviously lower, while scores of physical function, role function, cognitive function, emotional function, and social function were evidently higher than the control group（ P 〈 O. 01 ）. Occurrence rates of leukopenia, nausea and vomiting, liver and kidney function damage of the treatment group were obvi- ously lower than the control group （ P 〈 0.05 ）, and there was no significant difference in incidence rate of neurovirulence （ P 〉 0.05）. 8 weeks after chemotherapy, serum levels of MMP-2 and CA125 of the treatment group were remarkably lower than the control group（P 〈0. 01 ）. Conclusion Efficacy of calf spleen extractive for patients with ovarian epithelial malignant tumor trea- ted with postoperative chemotherapy is significant with less adverse reactions, and inhibition of serum levels of MMP-2 and CA125 may be related to the effect.

关 键 词：小牛脾提取物 恶性卵巢肿瘤 化疗 金属蛋白酶-2 糖蛋白抗原125 

分 类 号：R737.31[医药卫生—肿瘤]