放疗对头颈部恶性肿瘤患者的心血管疾病危险因素水平的影响  

The Influence of Radiotherapy on the Cardiovascular Disease Risk Factors Level of Head and Neck Malignant Tumors Patients

作　　者：张如楠[1] 武莉萍[1] 

机构地区：[1]河南省新乡市中心医院,453000

出　　处：《实用癌症杂志》2017年第11期1811-1813,共3页The Practical Journal of Cancer

摘　　要：目的探讨放疗对头颈部恶性肿瘤患者的心血管疾病危险因素水平的影响。方法以经病理确诊为头颈部恶性肿瘤并接受放疗的40例患者作为观察组;以病理确诊为头颈部恶性肿瘤但还未接受放疗的40例患者作为对照组。比较两组的收缩压(SBP)与舒张压(DBP)、总胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白-胆固醇(LDL-C)、高密度脂蛋白-胆固醇(HDL-C)、空腹血糖(FPG)和体重指数(BMI)水平。结果观察组的SBP、DBP、TC、TG、LDL-C和FPG水平均明显高于对照组(P<0.05),观察组的HDL-C水平明显低于对照组(P<0.05),两组的BMI差异不明显(P>0.05);放疗前后观察组高血压、血脂异常、超重或肥胖以及糖尿病的患病例数差异不具有统计学意义(P>0.05),但放疗后例数均略多于放疗前。结论放疗会影响头颈部恶性肿瘤患者CVD危险因素水平,CVD危险因素水平的监测可为对头颈部恶性肿瘤患者的CVD防治提供一定参考。Objective To study the influence of radiotherapy on the cardiovascular disease （CVD） risk factors level of head and neck malignant tumors patients. Methods Head and neck malignant tumor patients diagnosed by pathology treated with radiotherapy were the observation group （40 cases）. And head and neck malignant tumor patients without radiotherapy were the control group （40 cases）. Systolic blood pressure （SBP） and diastolic blood pressure （DBP）, total cholesterol （TC）, triglyceride （TG）, high-density lipoprotein cholesterol （LDL-C）, high density lipoprotein cholesterol （HDL-C）, fasting plasma glucose （FPG） and body mass index （BMI） level of the 2 groups were compared. Results The SBP, DBP,TC,TG, LDL-C and FPG of the observation group were significantly higher than those of the control group （ P 〈 0.05 ）, HDL-C of the observation group was significantly lower than that of the control group （P 〈 0.05 ）, BMI of 2 groups had no obvious difference （P 〉 0.05 ） ;The hyper- tension, dyslipidemia, overweight/obese and diabetes cases of the observation group before and after radiotherapy （ P 〉 0.05 ）, but the case after radiotherapy was slightly more than that before radiotherapy. Conclusion Radiotherapy can affect the CVD risk factors level of patients with head and neck malignant tumor radiotherapy. And CVD risk factors monitoring can provide certain reference for prevention and control of head and neck malignant tumors patients with CVD.

关 键 词：放疗 头颈部恶性肿瘤 心血管疾病 危险因素 

分 类 号：R739.91[医药卫生—肿瘤]