血栓弹力图预测静脉血栓栓塞症发生的价值分析  

A Systematic Review of the Value of Thrombelastography or Thromboelastometry for Prediction of Venous Thromboembolism

作　　者：蒋知云 马俊芬[1] 王倩[1] 吴凡[1] 平杰丹 明亮[1] 

机构地区：[1]郑州大学第一附属医院检验科河南省检验医学重点实验室,河南郑州450052

出　　处：《中国实验血液学杂志》2017年第5期1498-1503,共6页Journal of Experimental Hematology

基　　金：河南省科技攻关计划项目(152102410067;162102310142);河南省教育厅科学技术研究重点项目(13A310622)

摘　　要：目的:系统搜集有关血栓弹力图预测静脉血栓栓塞症(venous thromboembolism,VTE)的临床研究文献,评价血栓弹力图在预测血栓发生事件中的应用价值。方法:计算机检索Pub Med,Central,Embase数据库中的相关临床实验研究文献,并手工检索相关参考文献,然后运用QUADAS-2工具对纳入文献的质量进行评价,最终对纳入的研究进行定性分析。结果:共纳入研究15篇,涉及293名VTE患者。纳入文献的质量及血栓弹力图预测VTE的准确性参差不齐。三分之二的研究显示,血栓弹力图参数的变化可以预测VTE的发生。结论:目前的研究显示,血栓弹力图预测VTE的准确性差异较大。血栓弹力图联合血栓与止血的其它实验室检测指标可能会提高预测VTE发生的准确性。Objective： To systematically collect the thrombelastography（TEG）-or thromboelastometry（ROTEM）-related data,and predict to evaluate their values for the prediction of thromboembolic events. Methods： Databases including PubMed,Central and Embase were searched for the related clinical trials,and the references were retrieved manually; these included references were assessed qualitatively by the QUADAS-2 tool; finally the enrolled researches were qualitatively analyzed. Results： A total of 15 studies consisting of 293 VTE patients met the inclusion criteria. The overall quality and the accuracy of TEG or ROTEM in predicting VTE varied a lot. Two thirds of the studies displayed that the changes of TEG parameters or ROTEM were related to the occurrence of VTE. Conclusion： The present studies showed that the TEG or ROTEM for predicting the VTE display higher difference in accuracy,therefore,the combination of TEG or ROTEM with other laboratory tests may improve the accuracy of VTE diagnosis.

关 键 词：静脉血栓栓塞症 血栓弹力图 血栓弹力测定 深静脉血栓形成 

分 类 号：R364.15[医药卫生—病理学]