p16抑癌机制及其在鼻腔-鼻窦鳞状细胞癌中的研究进展  

Research Progress of p16 Gene in Sinonasal Squamous Cell Carcinoma

作　　者：王佳说 阎艾慧[1] WANG Jiashuo YAN Aihui.(Department of Otorhinola~ngology, the First Hospital of China Medical University, Shenyang 110001, China)

机构地区：[1]中国医科大学附属第一医院耳鼻咽喉科,沈阳110001

出　　处：《医学综述》2017年第21期4231-4235,4240,共6页Medical Recapitulate

摘　　要：抑癌p16基因通过编码p16蛋白,诱导细胞分化,抑制细胞过度分裂,维持细胞周期稳态;p16基因通过多种方式失活,导致p16蛋白表达异常,从而广泛参与人类恶性肿瘤的发生。p16表达受到视网膜母细胞瘤蛋白负反馈、人乳头瘤病毒感染等机制的调控,其表达异常在鼻腔-鼻窦鳞状细胞癌(SNSCC)发生过程中具有重要作用,并且可以作为SNSCC临床、病理特点的检测相关因子。因此,了解p16的作用机制、检测p16的表达情况对于明确SNSCC的发生基础、肿瘤恶性程度、发展进程及预后均具有重要意义。The p16 gene induces cell differentiation, inhibits cell over-division and maintains cell cycle homeostasis through coding p16 protein; the inactivation of p16 gene through a variety of ways results in abnormal expression of p16 protein,which is widely involved in the occurrence of human malignant tumors, p16 expression is regnlated by retinoblas- toma protein negative feedback and human papillomavirus infection. The abnormal p16 protein expression is closely related to the occurrence of sinonasal squamous cell carcinoma（ SNSCC）, and can be used as its relevant factors of the clinical and pathological characteristics. Therefore, understanding the action mechanism of p16, the detection of p16 expression is of great significance for clarifying the occurrence,tumor malignancy, development process and prognosis of SNSCC.

关 键 词：鼻腔-鼻窦鳞状细胞癌 P16蛋白 抑癌基因 

分 类 号：R739.62[医药卫生—肿瘤]