胃癌手术标本中脉管癌栓的临床意义  

The clinical significance of lymphovascular invasion in gastric cancer tissues

作　　者：叶再生[1] 魏晟宏[1] 林振孟 王益[1] 曾奕[1] 李阳明[1] 肖军[1] 陈路川[1] 

机构地区：[1]福建医科大学附属肿瘤医院胃肠外科,福州350014

出　　处：《中华普通外科杂志》2017年第10期816-819,共4页Chinese Journal of General Surgery

摘　　要：目的分析脉管癌栓与胃癌患者临床病理特征的关系及其对预后的影响。方法回顾性分析1482例行胃癌根治术后患者的临床病理资料，评价脉管癌栓与患者预后的关系。结果1482例胃癌患者中有606例（40．9％）存在脉管癌栓，脉管癌栓与肿瘤大小、肿瘤位置、Borrmann分型、肿瘤分化程度、手术方式、侵犯深度、淋巴结转移、TNM分期均有关（均P〈0．05）。脉管癌栓阳性胃癌患者的5年生存率低于阴性患者（55．0％比73．1％，χ2=45．15，P=0．00）。多因素分析结果显示，脉管癌栓是判断胃癌患者预后的独立因素（HR=1．592，95％CI：1．329～1．907，P=0．00）。结论脉管癌栓是判断胃癌患者预后的重要指标；脉管癌栓阳性的胃癌患者预后更差。Objective To analyze the relationship of lymphovascular invasion （LVI） and the clinical pathological feature of gastric cancer and impact on the prognosis in gastric cancer patients. Methods The clinical and pathological data of 1 482 gastric cancer patients undergoing gastrectomy were analyzed retrospectively. The relationship between LVI and the prognosis was evaluated. Results LVI was found in 606 patients （40. 9% ）, which was in significant correlations with tumor size, tumour location, Borrmann type, tumor differentiation status, operative method, tumor invasion, lymph node involvement, and TNM stage （ P 〈 0. 05 ）. The five-year survival of patients with LVI was significantly shorter than that of the LVI-negative patients （55.0% vs. 73.1%, χ2 =45.15, P =0.00）. By multivariate analysis, LVI was an independent prognostic factor （HR = 1. 592, 95% CI： 1. 329 - 1. 907,P = 0.00）. Conclusion LVI is an important indicator for poor prognosis of gastric cancer, suggesting a more aggressive postoperative therapies.

关 键 词：胃肿瘤 肿瘤转移 病理学 临床 预后 

分 类 号：R735.2[医药卫生—肿瘤]