瑞舒伐他汀防治颈动脉支架术后再狭窄的临床疗效评价  

Clinical efficacy of rosuvastatin in prevention of restenosis after carotid artery stenting

作　　者：牛启兵[1] 石朝海 李安强[1] 陈泉[1] 张苏钰[1] 温世奇[1] 

机构地区：[1]甘肃省人民医院血管外科,兰州730000

出　　处：《中华老年多器官疾病杂志》2017年第10期755-758,共4页Chinese Journal of Multiple Organ Diseases in the Elderly

摘　　要：目的观察瑞舒伐他汀防治颈动脉支架植入(CAS)后再狭窄的疗效。方法分析2014年3月至2015年8月我院收住的69例CAS后患者,随机分为对照组(34例)和治疗组(35例),对照组口服拜阿司匹林100 mg/d,治疗组口服拜阿司匹林100 mg/d、瑞舒伐他汀10 mg/d,连续治疗12个月,对两组的疗效进行评价分析。根据数据类型分别采用t检验、方差分析或X^2检验进行组间比较。结果颈动脉支架置入后12个月时复查颈动脉CT血管成像发现,治疗组支架光滑度、支架内径、支架近端和远端血管情况均优于对照组(P<0.01),支架内管腔密度值、支架内再狭窄率均低于对照组(P<0.01);治疗组血浆总胆固醇(TC)和低密度脂蛋白胆固醇(LDL-C)较治疗前显著降低(P<0.01)、血浆脂联素(APN)较治疗前显著升高(P<0.01),对照组TC、LDL-C、APN较治疗前差异无统计学意义(P>0.05)。结论颈动脉支架置入后口服瑞舒伐他汀对于预防支架后再狭窄闭塞效果显著,可降低再狭窄率。Objective To investigate the efficacy of rosuvastatin in the prevention of carotid restenosis after carotid artery stenting （CAS）. Methods Sixty-nine patients who had undergone CAS in our hospital from March 2014 to August 2015 were recruited prospectively,and then randomly assigned to the control group（n=34,bayaspirin 100 mg/d） and treatment group（n=35,bayaspirin 100 mg/d and clopidogrel 75 mg/d）. After oral administration for 12 months, the therapeutic effects were compared between the 2 groups. SPPS statisitics 17.0 was used. The data were analyzed by t test, variance analysis, or Chi-square test. Results At 12 months post-CAS,repeated CT angiography showed that the treatment group was superior to the control group in stent smoothness,stent inner diameter,as well as the vascular conditions at the proximal and distal ends of the stent （P〈0.01）, and in lower stent lumen density and stent restenosis rate （P〈0.01）. In the treatment group,the levels of total cholesterol （TC） and low-density lipoprotein cholesterol （LDL-C） were significantly decreased （P〈0.01）, while that of adiponectin （APN） was obviously increased after the treatment （P〈0.01）. However, no changes were found in the levels of TC, LDL-C, or APN in the control group （P 〉0.05）. Conclusion Oral administration of rosuvastatin exerts significant effect on the prevention of post-CAS in-stent restenosis and occlusion,and thus reduces the restenosis rate.

关 键 词：瑞舒伐他汀 颈动脉支架植入术 再狭窄 

分 类 号：R743.9[医药卫生—神经病学与精神病学]