NOS1基因rs3782206多态性对反应抑制的影响:事件相关电位研究  

The contribution of NOS1 gene polymorphism(rs3782206) to response inhibition:an ERP study

作　　者：韩冰倩 赵琬 张志芳[1] 黄玲[1] 李君[1] 

机构地区：[1]北京师范大学认知神经科学与学习国家重点实验室及IDG/麦戈文脑科学研究院,北京100875

出　　处：《济宁医学院学报》2017年第5期333-337,共5页Journal of Jining Medical University

基　　金：973项目(2014CB846102);国家自然科学基金面上项目(81571045)

摘　　要：目的探讨神经型一氧化氮合成酶基因(NOS1)rs3782206多态性与反应抑制能力的相关性。方法以132名健康被试为研究对象,通过偏相关分析,验证NoGo-N2效应与反应抑制能力是否有显著相关性。根据rs3782206基因型将被试分为风险等位基因(T)携带者组和非携带者组。通过协方差分析比较不同基因型组完成点阵图预期任务(DPX任务)时探测刺激阶段N2差异波(N2_(AY-AX))波幅是否存在差异。结果在控制了协变量年龄、性别和工作记忆能力(E_(BX-AY))后,差异波N2_(AY-AX)的波幅与E_(AY)显著相关(r=0.21;P<0.05)。风险等位基因携带者组的差异波N2_(AY-AX)波幅显著大于非携带者组,差异具有统计学意义(F=4.73;P<0.05)。结论验证了以NoGo-N2效应作为反应抑制能力电生理指标的正确性。并进一步发现NOS1rs3782206主要通过影响反应抑制功能发挥精神分裂症易感作用。Objective To explore the association of the NOS1 gene polymorphism（rs3782206） with response inhibition Methods 132 healthy subjects were involved in this study and divided into two groups according to the genotype of rs3782206. Partial correlation was used to test the relationship between NoGo-N2 and response inhibition. ANCOVA was used to test the difference between genotypes on the amplitude of the difference wave of the probe-phased N2（N2_（AY-AX））.Results After controlling for covariates,the amplitude of the differential wave N2_（AY-AX） was correlated significantly with EAY（r = 0. 21;P = 0. 020）. The TT/TC genotype group had higher amplitude of N2_（AY） vs. N2_（AX） than the CC genotype group（ F = 4. 73;P = 0. 032）. Conclusion These findings provide the evidence for the validity of using E_（AY） as a measure of response inhibition and suggest that the response inhibition may be a possible cognitive mechanism underlying the association between NOS1 gene polymorphism rs3782206 and schizophrenia.

关 键 词：点阵预期任务 事件相关电位 精神分裂症 NOS1基因 反应抑制 

分 类 号：R749[医药卫生—神经病学与精神病学]