探讨阿司匹林联合尼莫地平对偏头痛患者头痛发作频率的影响  

Investigation on effect of aspirin combined with nimodipine on the frequency of headache attacks in migraine patients

作　　者：杨颖[1] 李雪媛[1] 张静波[1] 于晓铃 

机构地区：[1]大连市第三人民医院神经内科,116031

出　　处：《中国现代药物应用》2017年第20期91-92,共2页Chinese Journal of Modern Drug Application

摘　　要：目的探讨阿司匹林联合尼莫地平对偏头痛患者头痛发作频率的影响。方法 80例偏头痛患者,随机分为对照组和试验组,每组40例。对照组采取阿司匹林肠溶片进行治疗,试验组在对照组基础上使用尼莫地平联合治疗。比较两组患者头痛发作频率和持续时间。结果治疗前两组患者头痛发作频率、持续时间比较差异无统计学意义(P>0.05)。治疗后两组患者头痛发作频率、持续时间均优于治疗前,差异有统计学意义(P<0.05);且试验组发作频率为(7.11±0.75)次/月、持续时间为(2.78±0.27)h,均优于对照组的(15.22±2.11)次/月、(5.96±0.53)h,差异有统计学意义(P<0.05)。结论阿司匹林联合尼莫地平治疗偏头痛,可以明显降低患者的头痛发病频率和发病持续时间,值得在临床推广。Objective To discuss the effect of aspirin combined with nimodipine on the frequency of headache attacks in migraine patients. Methods A total of 80 migraine patients were randomly divided into control group and experimental group, with 40 cases in each group. The control group was treated with aspirin enteric-coated tablets, and the experimental group was treated with nimodipine on the basis of the control group. Comparison were made on frequency and duration of headache attacks between two groups. Results Before treatment, both groups had no statistically significant difference in frequency and duration of headache attacks（P〈0.05）. After treatment, both groups had better frequency and duration of headache attacks than before treatment, and the difference was statistically significant（P〈0.05）. The experimental group had frequency of headache attacks as（7.11±0.75） times/month, and duration of headache attacks as（2.78±0.27） h, which were all better than（15.22±2.11） times/month and（5.96±0.53） h in the control group, and their difference was statistically significant（P〈0.05）. Conclusion Combination of aspirin and nimodipine can significantly reduce the frequency and duration of headache attacks in treating migraine, and it is worthy of clinical promotion.

关 键 词：阿司匹林 尼莫地平 偏头痛 

分 类 号：R747.2[医药卫生—神经病学与精神病学]