乳腺癌MRI表现与Ki-67、E-cad表达的关系  

Correlation between magnetic resonance imaging manifestations and expression of Ki-67 and E-cad in patients with breast cancer

作　　者：周寨文[1] 张延伟 曾道辉[1] 简润强[1] 王慧 ZHOU Zhaiwen ZHANG Yanwei ZENG Daohui JIAN Runqiang WANG Hui(Department of lmaging, First Affiliated Hospital of Guangzhou University of Traditional Chinese Medicine, Guangzhou 510405, China Department of Imaging, Third Affiliated Hospital of Guangzhou University of Traditional Chinese Medicine, Guangzhou 510240, China First Affiliated Hospital of Henan University of Chinese Medicine, Zhengzhou 136300, China)

机构地区：[1]广州中医药大学第一附属医院影像科,广东广州510405 [2]广州中医药大学第三附属医院影像科,广东广州510240 [3]河南省中医药大学第一附属医院,河南郑州136300

出　　处：《中国医学物理学杂志》2017年第10期1008-1012,共5页Chinese Journal of Medical Physics

基　　金：广东省中医药管理局基金(20162070)

摘　　要：目的:探讨乳腺癌MRI表现与Ki-67、E-cad表达的关系。方法:对经病理证实的60例乳腺癌患者的病理切片行Ki-67、E-cad免疫组化检测,观察MRI表现[大小、形状、边缘、强化形式、有无淋巴结转移、时间-信号强度曲线(TIC)类型、最大增强斜率],并将二者进行相关性分析。结果:病变大小与Ki-67阳性表达呈正相关(r=0.298,P<0.05);病变边缘为不规则或毛刺时,其Ki-67阳性表达率较高(r=0.319,P<0.05);不伴有淋巴结转移的患者E-cad阳性表达率越高(r=-0.349,P<0.05);病变倾向于TICⅢ型时,Ki-67阳性表达率高(r=0.574,P<0.01)。结论:乳腺癌MRI表现可以部分反映肿瘤的生物学行为,为预测肿瘤预后及临床治疗提供一定帮助。Objective To explore the correlation between magnetic resonance imaging（MRI） manifestations of breast cancer and expression of Ki-67 and E-cad. Methods The pathological sections of 60 patients with pathologically confirmed breast cancer were examined with Ki-67 and E-cad immunohistochemical testing. We observed their breast MRI manifestations, including the size, shape and edge of lesions, enhancement type, with or without lymph node metastases, time-signal intensity curve（TIC）type and maximum strengthening slope, and analyzed the relationship between MRI manifestations and the expression of Ki-67 and E-cad. Results The size of lesion was positively related with the positive expression of Ki-67（r=0.298, P〈0.05）. When the edge of lesion was irregular or had burrs, the positive rate of Ki-67 was higher（r=0.319, P〈0.05）. Patients with lesions tending to TIC Ⅲ had a higher positive rate of Ki-67（r=0.574, P〈0.01）, and those without lymph node metastasis had a higher positive rate of E-cad（r=-0.349, P〈0.05）. Conclusion Breast MRI findings may partly reflect the biological behavior of tumor and provide some help for the prediction of prognosis and treatment.

关 键 词：乳腺癌 磁共振成像 KI-67 E-CAD 

分 类 号：R737.9[医药卫生—肿瘤]