唇腭裂患儿中枢听觉神经系统的事件相关电位研究  

Event-related potential study of central auditory nervous system of children with cleft lip and/or palate

作　　者：束煌[1] 杨峰[2] 丁桂聪[1] 肖宇寒[3] 王骥[1] SHU Huang YANG Feng DING Gui-cong XIAO Yu han WANG Ji(Department of Stomatology Department of Speech Therapy Evoked Potentials Laboratory,Shenzhen Children＇s Hospital, Guangdong Shenzhen 518026, China.)

机构地区：[1]深圳市儿童医院口腔科,广东深圳518026 [2]深圳市儿童医院言语治疗科,广东深圳518026 [3]深圳市儿童医院诱发电位室,广东深圳518026

出　　处：《临床口腔医学杂志》2017年第10期620-622,共3页Journal of Clinical Stomatology

基　　金：深圳市科创委基础研究项目(JCYJ20150403100317070)

摘　　要：目的:通过研究唇腭裂患儿的事件相关电位(ERP)中P300成分的特征,调查唇腭裂患儿中枢听觉神经系统(CANS)可能的功能异常。方法:选取3~6岁唇腭裂患儿46名,分为单纯唇裂组,不完全腭裂组,单侧唇腭裂组及双侧唇腭裂组,分别检测患儿的事件相关电位中P300成分,并选择年龄相匹配的正常儿童40例作为对照组,进行组间比较。结果:与正常儿童相比,唇腭裂患儿的P300潜伏期显著延长(P<0.05),波幅显著降低(P<0.05),差异有统计学意义。唇腭裂患儿组间比较,3个腭裂组间差异无统计学意义,但与单纯唇裂组间对比,差异均有统计学意义(P<0.05)。结论:唇腭裂患儿的中枢听觉神经系统可能存在功能障碍。功能障碍与腭裂密切相关,但与腭裂类型无关。Objective：To investigate possible functional abnormalities of the central auditory nervous system（CANS）of children with cleft lip and/or palate.Methods：Forty-Six children with cleft lip and/or palate,aged from 3 to 6 years,were divided into 4 groups of cleft lip only,incomplete cleft palate only,unilateral complete cleft palate with cleft lip and bilateral complete cleft palate with cleft lip,and Forty normal infants were as control group.Event-related potential（ERP） P300 were selected as index to observe the function of central auditory nervous system of children in both groups.The data were statistically compared between groups.Results：Compared with the normal controls,the latency of the event-related potential P300 of children with cleft lip and/or palate was significantly prolonged（P〈0.05）,and the amplitude was significantly decreased（P〈0.05）.No significant group differences were found in 3 groups of incomplete cleft palate only,unilateral complete cleft palate with cleft lip and bilateral complete cleft palate with cleft lip,but significant group differences were found in cleft lip only between 3 groups of cleft palate（P〈0.05）,respectively.Conclusion：Children with cleft lip and/or palate may have dysfunction of central auditory nervous system.Dysfunction is closely related with the existence of cleft palate,but not with the cleft palate type.

关 键 词：唇腭裂 中枢听觉神经系统 事件相关电位 

分 类 号：R782.2[医药卫生—口腔医学]