不同程度抑郁症患者认知功能及事件相关电位P300的研究  

Cognitive function and event related potential P300 among different severity depressive patients

作　　者：段敬利[1] 潘伟盟[2] 穆俊林[1] 田晓杰[2] 张朝辉[3] 

机构地区：[1]河南新乡医学院第二附属医院神经电生理科,453002 [2]河南新乡医学院第二附属医院精神科,453002 [3]河南新乡医学院第二附属医院心身疾病科,453002

出　　处：《临床精神医学杂志》2017年第5期327-330,共4页Journal of Clinical Psychiatry

基　　金：河南省科技发展计划支持项目(132300410162)

摘　　要：目的:探讨抑郁症患者认知功能损害特点,及其与事件相关电位(ERP)P300的关系。方法:64例诊断符合《国际疾病分类》第10版(ICD-10)的抑郁症患者分为30例中重度抑郁症组(A组)和34例轻度抑郁症组(B组);对其分别进行威斯康星卡片分类测验(WCST)、韦氏成人记忆量表(WMS)和ERP-P300检查,并与30例正常对照者(C组)进行对比,分析WCST、WMS评分与P300指标的关系。结果:A组WCST中完成分类数(Cc)、持续性错误数(Rpe)、随机错误数(NRpe),WMS中长时记忆、短时记忆、瞬时记忆、记忆商数、P300的N2、P3a、P3b潜伏期和波幅与C组间差异有统计学意义(P均<0.05);B组Cc、NRpe、短时记忆、瞬时记忆、记忆商数、P300的N2、P3a、P3b波幅与C组间差异有统计学意义(P均<0.05);A组Cc、Rpe、长时记忆、记忆商数及P300的N2、P3a、P3b潜伏期与B组之间差异有统计学意义(P<0.05),且ERP-N2、P3b潜伏期与长时记忆分呈负相关(r=-0.467,-0.523,P<0.05);P300的N2、P3a、P3b潜伏期与Rpe呈正相关(r=0.657,0.573,0.763,P<0.05);ERP-N2、P3b波幅与短时记忆和瞬时记忆分呈正相关(r=0.478,0.434,0.532,0.541;P均<0.05),与NRpe呈负相关(r=-0.489,-0.532,P均<0.05)。结论:抑郁症患者存在注意转移、记忆、执行功能等方面的认知功能障碍,抑郁程度与其认知功能损害的程度相关,P300指标的异常可反映认知功能损害。Objective： To explore the characteristic of cognitive impairments in depressive patients and analyze its correlation with the endogenous components of event-related potentials（ ERP） P300. Method： 64 cases patients meeting international classification of diseases（ ICD-10） criteria for the diagnosis of depression were divided into moderate to severe depression group（ group A,n = 30） and 34 cases of mild depression group（ group B,n = 30）. Wisconsin card sorting test（ WCST）,Wechsle memory scale（ WMS） in adults and ERPP300 examinations were conducted to them,and the data were compared with 30 cases of normal control group（ group C,n = 30） to analyze the differences of them and correlation analysis were performed between the former indicators and the endogenous components of ERP-P300. Results： There were statistical significance between group A and C in the complete number of categories（ Cc）,perseverative error（ Rpe）,non-perseverative error（ NRpe） of WCST,long-term memory、short-term memory,immediate memory,memory quotient of WMS,latencies and amplitudes of ERP-N2,P3 a,P3 b（ all P 0. 05）. There were statistical significance between group B and C in Cc,NRpe,short-term memory,immediate memory,memory quotient,the amplitudes of N2,P3 a,P3 b（ all P 0. 05）. There were statistical significance between group A and B in Cc,Rpe,long-term memory,memory quotient,the latencies of CN2,P3 a,P3 b（ P 0. 05）. The latencies of N2、P3 b had negative correlation with the scores of long-term memory（ r =-0. 467,-0. 523,P 0. 05） and the latencies of N2、P3 a、P3 b had positive correlation with Rpe（ r = 0. 657,0. 573,0. 763; all P 0. 05）,the amplitudes of N2、P3 b had positive correlation with the scores of short-term memory and immediate memory（ r = 0. 478,0. 434,0. 532,0. 541; all P 0. 05）and negative correlation with NRpe（ r =-0. 489,-0. 532; all P 0. 05）. Conclusion： depressive patients have cognitive dysfunctions in shifting of attention,memory and executive

关 键 词：抑郁症 认知功能 事件相关电位P300 

分 类 号：R749.3[医药卫生—神经病学与精神病学]