生长抑素、乌司他丁联合早期肠内营养治疗重症胰腺炎的临床分析  

Clinical analysis of somatostatin and ulinastatin combined with early enteral nutrition in the treatment of severe acute pancreatitis

作　　者：陈建生 CHEN Jian-sheng.(Department of General Surgery, Suzhou Science and Technology City Hospital, Suzhou 215153, China)

机构地区：[1]苏州科技城医院普外科,215153

出　　处：《中国实用医药》2017年第29期104-106,共3页China Practical Medicine

摘　　要：目的探讨生长抑素、乌司他丁联合早期肠内营养治疗重症胰腺炎的临床效果。方法 90例重症胰腺炎患者,随机分为观察组和对照组,每组45例。对照组采用生长抑素治疗,观察组在此基础上给予乌司他丁联合早期肠内营养治疗。对比分析两组患者的临床效果。结果观察组患者治疗总有效率(91.11%)优于对照组(73.33%),差异具有统计学意义(P<0.05)。观察组患者腹痛腹胀缓解时间、白细胞恢复时间、血清淀粉酶恢复时间及住院时间均短于对照组,差异具有统计学意义(P<0.05)。治疗后观察组患者的血及尿淀粉酶、血钙、白细胞计数均优于对照组,差异具有统计学意义(P<0.05)。观察组患者不良反应总发生率为24.44%,与对照组的28.89%对比,差异无统计学意义(P>0.05)。结论生长抑素、乌司他丁联合早期肠内营养治疗急性重症胰腺炎,可有效缓解腹胀腹痛症状,并缩短血清淀粉酶、白细胞恢复时间、住院治疗时间,对急性重症胰腺炎的治疗更有效果,治愈率也更高,建议在临床治疗中大量应用。Objective To investigate the clinical effect of somatostatin and ulinastatin combined with early enteral nutrition in the treatment of severe acute pancreatitis.Methods A total of 90 severe acute pancreatitis patients were randomly divided into observation group and control group,with 45 cases in each group.The control group was treated with somatostatin,and the observation group was also treated with ulinastatin and early enteral nutrition.Clinical effect in two groups was compared and analyzed.Results The observation group had better total treatment effective rate（91.11%）than the control group（73.33%）,and the difference was statistically significant（P〈0.05）.The observation group had shorter remission time of abdominal pain and abdominal distension,recovery time of leukocytes,recovery time of serum amylase and hospitalization time than the control group,and their difference was statistically significant（P〈0.05）.After treatment,the observation group had better amylase in blood and urine,blood calcium and white blood cell count than the control group,and their difference was statistically significant（P〈0.05）.The observation group had no statistically significant difference in incidence of adverse reactions as 24.44%,comparing with 28.89%in the control group（P〉0.05）.Conclusion Combination of somatostatin,ulinastatin and early enteral nutrition can effectively relieve the symptoms of abdominal distension and abdominal pain,shorten serum amylase,recovery time of serum amylase and leukocytes and hospitalization time in treating severe acute pancreatitis.It shows better effect in treating severe acute pancreatitis with higher cure rate,and suggested to be widely applied in clinical treatment.

关 键 词：生长抑素 乌司他丁 重症胰腺炎 早期肠内营养 

分 类 号：R576[医药卫生—消化系统]