乏氧诱导因子在疾病中作用机制的研究进展  

Review of retinal receptors and molecular imaging

作　　者：孟媛媛 杨福军[1] 徐文清[1] Meng Yuanyuan Yang Fujun Xu Wenqing(Tianjin Key Laboratory of Radiation Medicine and Molecular Nuclear Medicine, Institute of Radiation Medicine, Chinese Academy of Medical Sciences, Peking Union Medical College, Tianjin 300192, China)

机构地区：[1]中国医学科学院北京协和医学院放射医学研究所天津市放射医学与分子核医学重点实验室,天津300192

出　　处：《国际放射医学核医学杂志》2017年第5期347-352,369,共6页International Journal of Radiation Medicine and Nuclear Medicine

基　　金：国家自然科学基金（81273005）;天津市应用基础与前沿技术研究重点项目（14JCZDJC36400）;中国医学科学院放射医学研究所发展基金（SFl528）

摘　　要：乏氧诱导因子（HIF）是维持体内代谢平衡的一个重要因子，目前对其研究已成为热点。以往的研究证实，HIF与众多疾病都有着密切的关系，如炎症、肿瘤以及辐射损伤。笔者简述国内外有关HIF的研究成果，为HIF作为治疗靶点的深入研究提供新思路。Retinal synthetic functions are adjusted by various neurotransmitters（e.g.,γ-aminobutyric acid, dopamine, 5-hydroxytryptamine, and σ receptor） and can be visualized through nuclear receptor imaging. This technology has rapidly advanced in recent years with the development of nuclear medical equipment and agents. Retinal receptor imaging has become a pioneer medical technique that combines molecular biology, nuclear medicine, and ophthalmology. This article provides a brief introduction on the latest advances in retinal neurotransmitters and describes recent studies on retinal receptor molecular imaging.

关 键 词：乏氧诱导因子 辐射防护 辐射损伤 肿瘤 炎症 

分 类 号：R363[医药卫生—病理学]