生长抑素联合清胰汤治疗重症急性胰腺炎的临床效果观察  

Clinical effects of somatostatin combined with Qingyi decoction in the treatment of acute pancreatitis

作　　者：杨会军[1] 

机构地区：[1]北京市怀柔区中医医院外科,北京市101400

出　　处：《中国基层医药》2017年第22期3430-3434,共5页Chinese Journal of Primary Medicine and Pharmacy

摘　　要：目的 探讨生长抑素联合清胰汤治疗重症急性胰腺炎的临床效果.方法 选取重症急性胰腺炎患者120例为研究对象,按照随机数字表法将其分为观察组与对照组,对照组患者采用生长抑素治疗,观察组患者在此基础上联合清胰汤治疗,比较两组临床疗效、临床指标及症状改善、不良反应发生情况.结果 观察组总有效率（100.00%）较对照组高（90.00%）,差异有统计学意义（χ2=6.316,P〈0.05）.治疗前两组临床指标差异均无统计学意义（t=0.047、0.069、0.040、0.279、0.064、0.101、0.333,均P〉00.05）.治疗后观察组白蛋白较对照组高,白细胞计数、APACHEⅡ评分、C反应蛋白、血淀粉酶、门冬氨酸氨基转移酶及乳酸脱氢酶均较对照组低,差异均有统计学意义（t=14.822、11.654、15.849、20.000、10.509、15.213、15.191,均P〈0.05）.观察组血淀粉酶恢复正常、腹痛缓解、排气恢复、胃肠功能恢复、尿淀粉酶恢复正常、腹胀缓解、呼吸机撤离、腹部压痛消失时间等均短于对照组,住院时间较对照组短,差异均有统计学意义（t=10.479、15.855、8.705、13.064、8.965、11.783、11.347、17.069、7.058,均P〈0.05）.对照组不良反应发生率较观察组高,差异有统计学意义（11.67%比1.67%,χ2=4.821,P〈0.05）.结论 生长抑素联合清胰汤可显著改善重症急性胰腺炎患者临床症状,临床疗效及安全性佳.Objective To investigate the clinical effects of somatostatin combined with Qingyi decoction in the treatment of acute pancreatitis. Methods 120 patients with acute pancreatitis were chosen as observation subjects,and they were randomly divided into control group and observation group according to the digital table. The control group was treated with somatostatin,the observation group was treated with Qingyi decoction on the basis of control group. The clinical effects,improvements of clinical indicators and symptom,adverse reaction between the two groups were compared. Results The total effective rate of the observation group（100. 00%） was higher than that of the control group（90. 00%）,the difference was statistically significant （χ2 =6. 316,P〈0. 05）. Before treatment, there were no statistically significant differences between the two groups in clinical indicators （ t =0. 047,0. 069, 0. 040,0. 279,0. 064,0. 101,0. 333,all P〉00. 05）. After treatment,the albumin of the observation group was higher than that of the control group,white blood cell count,APACHEⅡ score,C reactive protein,serum amylase,aspartate aminotransferase and lactate dehydrogenase were lower than those in the control group, the differences were statistically significant （t=14. 822,11. 654,15. 849,20. 000,10. 509,15. 213,15. 191,all P〈0. 05）. The blood amylase,abdominal pain relief,recovery of gastrointestinal function,urinary amylase,abdominal distension,ventilator weaning,abdominal tenderness disappeared and so on symptom improvement time of the observation group were earlier than those of control group,the hospital stay was shorter than that of the control group,the differences were statistically significant （t=10. 479,15. 855,8. 705,13. 064,8. 965,11. 783,11. 347,17. 069,7. 058,all P〈0. 05）. The incidence rate of adverse reactions in the control group was higher than that in the observation group（11. 67% vs. 1. 67%）,the difference was statistically significant （χ2 = 4. 821, P〈0. 05 ）. Conclusion Q

关 键 词：胰腺炎 清胰汤 生长抑素 

分 类 号：R576[医药卫生—消化系统]