尤瑞克林联合丁苯酞对72例急性脑梗死患者血管内皮功能及神经功能的影响  

Effect of urinary kallikrein plus butylphthalide on endothelial and neurological functions in 72 cases of patients with acute cerebral infarction

作　　者：庄清芬[1] 苏为谦[1] ZHUANG Qingfen SU Weiqian(Department of Encephalopathy, Traditional Chinese Medicine hospital of Quanzhou, Quanzhou 362000, Chin)

机构地区：[1]福建省泉州市中医院脑病科,泉州362000

出　　处：《上海医药》2017年第21期16-18,37,共4页Shanghai Medical & Pharmaceutical Journal

摘　　要：目的:研究尤瑞克林联合丁苯酞治疗急性脑梗死的疗效及其对患者血管内皮功能及神经功能的影响。方法:选取144例急性脑梗死患者并随机均分为实验组和对照组。所有患者均接受常规支持治疗,对照组在此基础上予以尤瑞克林治疗,实验组予以尤瑞克林联合丁苯酞治疗。比较分析两组的临床疗效,患者治疗前后的血浆一氧化氮(NO)、内皮素-1(ET-1)含量及神经功能缺损评分。结果 :治疗后,实验组的临床疗效优于对照组(P<0.05);两组患者的血浆NO均明显升高,而血浆ET-1明显降低,并且实验组的NO含量高于对照组,ET-1含量低于对照组(P<0.05);两组患者的NIHSS、CNFDS评分均明显下降,且实验组下降程度优于对照组(P<0.05)。两组安全性差异不显著。结论:尤瑞克林联合丁苯酞治疗急性脑梗死,能够有效改善患者血管内皮功能及神经功能,疗效显著。Objective：To explore the effect of urinary kallikrein plus butylphthalide on endothelial and neurological functions in the treatment of patients with acute cerebral infarction.Methods：One hundred and forty-four cases with acute cerebral infarction were randomly divided into a research group and a control group.Besides the conventional therapy,the control group was treated with urinary kallikrein and the research group with urinary kallikrein plus butylphthalide.The clinical effects,plasma nitric oxide,content of ET-1 and neurological deficit score were compared between the two groups.Results：The clinical effects were better in the research group than in the control group after treatment（P〈0.05）.The content of plasma nitric oxide was improved and the content of ET-1 was decreased in the two groups.The content of plasma nitric oxide was higher while the content of ET-1 was significantly lower in the research group than in the control group（P〈0.05）.The NIHSS and CNFDS scores were all decreased in both groups and the decrease was more significant in the research group（P〈0.05）.There were no differences between the two groups in the incidence of adverse reactions.Conclusion：Urinary kallikrein plus butylphthalide for the treatment of patients with acute cerebral infarction can improve the endothelial and neurological functions with remarkable curative effect.

关 键 词：急性脑梗死 尤瑞克林 丁苯酞 血管内皮功能 神经功能 

分 类 号：R743.3[医药卫生—神经病学与精神病学]