中西医结合逆转难治性急性白血病多药耐药的临床研究  

Clinical Study of Reversing Multidrug Resistance in Refractory Acute Leukemia by Integrated Traditional Chinese and Western Medicine

作　　者：沈向理[1] 张慧琪[1] 林霞[1] 黄静 

机构地区：[1]湖州市第一人民医院血液科,浙江湖州313000

出　　处：《中华中医药学刊》2017年第11期2966-2968,共3页Chinese Archives of Traditional Chinese Medicine

摘　　要：目的:探讨中西医结合逆转难治性急性白血病多药耐药的临床效果。方法:选择医院2010年3月—2016年9月之间收治的难治性急性白血病患者120例,按照完全随机数字法,将所有患者分成对照组和观察组,对照组进行常规化疗,观察组在对照组化疗方案基础上加中药进行联合治疗,比较两种治疗的效果。结果:在一般情况比较中,对照组与观察组在性别、年龄、白血病类型几个方面均未出现统计学差异(P>0.05),观察组的耐药蛋白P170水平与骨髓原始细胞百分比在治疗前后出现统计学差异(t=20.933,49.319,P<0.05),对照组的耐药蛋白P170水平与骨髓原始细胞百分比在治疗前后也出现统计学差异(t=5.718,31.838,P<0.05),观察组和观察组的耐药蛋白P170水平在治疗后出现统计学差异(t=11.021,P<0.05),观察组和对照组的骨髓原始细胞百分比在治疗后出现统计学差异(t=18.505,P<0.05),在对照组和观察组的疗效比较中,两个组别的数据出现了统计学差异(z=5.265,P<0.05),观察组的缓解情况明显优于对照组,在对照组和观察组的不良反应发生的比较中,在消化道反应、骨髓抑制和脱发三个项目上,均出现了统计学差异(χ2=6.171,6.536,12.079,P<0.05),观察组的不良反应发生情况明显优于对照组。结论:中西医结合的方法可以使有效的促进患者的症状缓解,提高治疗的效果,并且提高患者的免疫力,为难治性急性白血病患者的多药耐药的逆转问题提供了一个崭新的思路。Objective ： To explore the clinical effect of combining traditional Chinese and western medicine in reversing multidrug resistance of refractory acute leukemia. Methods ： A total of 120 patients with refractory acute leukemia were enrolled in our hospital from March 2010 to September 2016. All patients were divided into the control group and the observation group according to the completely random number method. The control group was treated with conventional chemotherapy. The observation group was treated with traditional Chinese medicine on the basis of chemotherapy, and the effects of two treatments were compared. Result ： In the general comparison, there were no significant differences in the gender, age or leukemia types between the control group and the observation group （P 〉0. 05）. The level of the resistance protein P170 in the observation group and the percentage of bone marrow blast cells appeared before and after treatment （t =5. 718, 31. 838, P 〈0. 05 ）. The difference between two groups was statistically significant （t = 20. 933, 49. 319, P 〈0. 05） , and the difference between the control group and the control group was statistically significant （t = 11. 021, P 〈 0. 05 ）. The percentages of bone marrow blast cells in the observation group and the control group were statistically different after treatment （z = 5. 265, P 〈 0. 05）. The observation group of remission was significantly better than that of the control group. In the comparison of adverse reactions between the control group and the observation group was statistical differences （χ^2= 6.171,6. 536, 12. 079, P 〈 0.05 ） in the three items of digestive tract reaction, bone marrow suppression and alopecia）. The incidence of adverse reactions in the observation group was significantly better than that of the control group. Conclusion： The combination of traditional Chinese and western medicine can effectively promote the symptoms of patients, the effect of treatment and the immunity of patients with re

关 键 词：中西医结合 难治性急性白血病 耐药性 

分 类 号：R733.7[医药卫生—肿瘤]