脾多肽注射液联合TACE治疗原发性肝癌的效果分析  

Effect Analysis of Lienal Polypeptide Injection Combined with TACE in the Treatment of Primary Liver Cancer

作　　者：应春花[1] 

机构地区：[1]青海省人民医院,西宁810000

出　　处：《基因组学与应用生物学》2017年第10期4000-4006,共7页Genomics and Applied Biology

基　　金：西宁市卫生计生委医学科研基金项目资助

摘　　要：为探讨脾多肽注射液联合经导管动脉化疗栓塞术治疗原发性肝癌的效果,本研究选取我院肝胆外科收治的原发性肝癌患者168例,按随机数字表法分为对照组和研究组。对照组84例予以经导管动脉化疗栓塞术(TACE)治疗,研究组84例在对照组基础上予以脾多肽注射液治疗。检查记录两组间肿瘤血供情况、血清肿瘤标志物水平、外周血免疫细胞水平,同时比较临床疗效及不良反应发生率。分析表明,其中研究组的治疗总有效率61.91%,远高于对照组,二者之间的差异显著(p<0.05);研究组和对照组相比,在治疗后肿瘤内动脉、肿瘤周边动脉血流分级水平较低,肿瘤周边门脉血流分级水平较高,治疗后血清AFP、CA19-9、GGT、AFU水平较低,治疗后外周血NK细胞、CD4^+、CD4^+/CD8^+比值水平较高,CD8^+T淋巴细胞水平较低,具有统计学意义(p<0.05);研究组恶心呕吐、食欲不振、白细胞减少、发热、乏力疲劳等不良反应的发生率低于对照组,具有统计学意义(p<0.05)。本研究表明,脾多肽注射液联合TACE治疗对于减少原发性肝癌患者肿瘤组织的血供,降低AFP、CA19-9、GGT、AFU水平,以及减轻TACE治疗对免疫功能的抑制作用,值得在临床上推广使用。In order to investigate the effect of lienal polypeptide injection combined with transcatheter arterial chemoembolization（TACE） in the treatment of primary liver cancer, 168 patients with primary liver cancer from the Department of Hepatobiliary Surgery in our hospital were selected and divided into the control group and the experiment group according to random number table method, 84 cases in the control group were treated with TACE, and the other 84 cases in the experiment group received lienal polypeptide injection on the basis of the control group. Tumor blood supply, serum tumor marker levels, peripheral blood immune cell levels, the clinical effect and incidence of adverse reactions of the two groups were compared after the treatment. The results showed that the total effective rate of the experiment group was 61.9%, which was much higher than that of the control group, and the difference between the two groups was significant（p〈0.05）. Compared with the control group,blood flow classification levels of intra tumor artery and peripheral tumor artery in the experiment group were lower. After treatment, the levels of serum AFP, CA19-9, GGT, and AFUB were lower, the NK cells, CD4^＋, and the ratio of CD4^＋/CD8^＋ were higher and the levels of CD8^＋T lymphocytes were lower, and the difference was statistically significant（p〈0.05）. The occurrence rates of adverse reactions such as nausea and vomiting, loss of appetite, leukopenia, fever, fatigue and fatigue in experiment group were lower than those in the control group, and the difference was statistically significant（p〈0.05）. This study showed that lienal polypeptide injection combined with TACE could significantly reduce the blood supply of tumor tissue in patients with primary liver cancer, the levels of AFP, CA19-9, GGT, AFU, and the inhibitory effect of TACE on immune function, which might worth application in clinical practice.

关 键 词：原发性肝癌 脾多肽注射液 彩超 AFP 疗效 

分 类 号：R735.7[医药卫生—肿瘤]