草酸艾司西酞普兰联合小剂量氨磺必利治疗以躯体症状为主老年抑郁症的疗性和安全性观察  

Observation of efficacy and safety of Escitalopram oxalate combined with small dose of Amisulpride in treatment of elderly depression with predominant somatic symptoms

作　　者：祝敬溪[1] 瞿颖莹 张喆[1] 陆丹 张霞波 陈明良 

机构地区：[1]江苏省常熟市第三人民医院,江苏常熟215500

出　　处：《中国民康医学》2017年第15期12-14,共3页Medical Journal of Chinese People’s Health

摘　　要：目的:观察草酸艾司西酞普兰联合小剂量氨磺必利治疗以躯体症状为主老年抑郁症的疗效和安全性。方法:采用随机数字表法将符合《国际疾病分类(第10版)》(ICD-10)抑郁症诊断标准的85例老年抑郁症患者分为研究组43例(采用草酸艾司西酞普兰联合氨磺必利治疗)和对照组42例(采用草酸艾司西酞普兰组),疗程8周。于治疗前和治疗后第1、2、4、6、8周末采用汉密尔顿抑郁量表17项版(HAMD-17)及症状自评量表(SCL-90)躯体化因子分评定并比较两组疗效及采用不良反应量表(TESS)评定安全性和不良反应。结果:治疗1周末,研究组的HAMD-17总评分与治疗前比有统计学差异性(P<0.05),治疗2周后,两组HAMD-17总评分与治疗前比较差异均有统计学意义(P<0.05)。治疗4周末,研究组HAMD-17和SCL-90躯体化因子总评分均较对照组低,比较差异有统计学意义(P<0.05);两组痊愈率及总有效率差异均有统计学意义(P<0.05)。研究组与对照组总体的不良反应发生率差异无统计学意义(P>0.05)。结论:草酸艾司西酞普兰联合小剂量氨磺必利治疗以躯体症状为主的老年抑郁症的疗效优于单纯草酸艾司西酞普兰治疗疗效,但其安全性等同。Objective： To observe efficacy and safety of Escitalopram oxalate combined with small dose of Amisulpride in treatment of elderly depression with predominant somatic symptoms. Methods： 85 elderly patients with depression,who met the depression criterion of ICD-10,were randomly divided into study group（ n = 43） and control group（ n = 42） according to the random number table method. The study group was treated with Escitalopram oxalate combined with small dose of Amisulpride,while the control group was treated with Escitalopram oxalate. 8 weeks was a course. The curative effects were evaluated with Hamilton depression scale-17 item（ HAMD-17） and somatization factors of symptom check list 90（ SCL-90） before and 1,2,4,6 and 8 weeks after the treatment,and the adverse reactions were assessed with treatment emergent symptom scale（ TESS）. Results： There was a statistical difference in the total HAMD-17 score of the study group before and 1 week after the treatment（ P〈0.05）. Further,There were the statistical differences in the total HAMD-17 score of the two groups before and 2 weeks after the treatment（ P〈0.05）. 4 weeks after the treatment,the HAMD-17 score and the total score of the somatization factors of SCL-90 of the study group were lower than those of the control group,and the differences were statistically difference（ P〈0.05）. The differences of the healing rate and total effective rate between the two groups were statistically significant（ P〈0.05）; however,the difference in the incidence of adverse reactions was not statistically significant（ P〈0.05）. Conclusions： In the treatment of elderly depression with predominant somatic symptoms,Escitalopram oxalate combined with small dose of Amisulpride is more effective than single Escitalopram oxalate,but they has equivalent safety.

关 键 词：草酸艾司西酞普兰 氨磺必利 老年抑郁症 

分 类 号：R749.4[医药卫生—神经病学与精神病学]